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- W3133765601 abstract "Abstract Chronic lymphocytic leukemia (CLL) is associated with physical dysfunction and low overall fitness that predicts poor survival following commencement of treatment. However, it remains unknown whether higher fitness in CLL patients provides anti-oncogenic effects. We identified ten fit (CLL-FIT) and ten less fit (CLL-UNFIT) treatment-naïve CLL patients from 144 CLL patients who completed a set of physical fitness and performance tests. Patient plasma was used to determine its effects on in vitro 5-day growth/viability of three B-cell cell lines (OSU-CLL, Daudi and Farage). Plasma exosomal miRNA profiles, circulating lipids, lipoproteins, inflammation levels, and immune cell phenotypes were also assessed. CLL-FIT was associated with fewer viable OSU-CLL cells at Day 1 ( p= 0.003), Day 4 ( p= 0.001) and Day 5 ( p= 0.009). No differences between groups were observed for Daudi and Farage cells. Of 455 distinct exosomal miRNAs identified, 32 miRNAs were significantly different between groups. Of these, 14 miRNAs had ≤-1 or ≥1 log2 fold differences. CLL-FIT patients had 5 exosomal miRNAs with lower expression and 9 miRNAs with higher expression. CLL-FIT patients had higher HDL cholesterol, lower inflammation, and lower levels of triglyceride components (all p <0.05). CLL-FIT patients had lower frequencies of low-differentiated NKG2+/CD158a/b neg ( p= 0.015 and p =0.014) and higher frequencies of NKG2A neg /CD158b+ mature NK-cells ( p= 0.047). Absolute numbers of lymphocytes including CD19+/CD5+ CLL-cells were similar between groups ( p =0.359). Higher physical fitness in CLL patients is associated with altered CLL-like cell line growth in vitro , and with altered circulating and cellular factors indicative of better immune functions and tumor control." @default.
- W3133765601 created "2021-03-15" @default.
- W3133765601 creator A5007388681 @default.
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- W3133765601 date "2021-03-02" @default.
- W3133765601 modified "2023-09-23" @default.
- W3133765601 title "Higher Physical Fitness Regulates In Vitro Tumor Cell Growth in Older Adults with Treatment Naïve Chronic Lymphocytic Leukemia (CLL)" @default.
- W3133765601 cites W1747288778 @default.
- W3133765601 cites W1902656250 @default.
- W3133765601 cites W1964085099 @default.
- W3133765601 cites W1969205863 @default.
- W3133765601 cites W1973094248 @default.
- W3133765601 cites W1973421470 @default.
- W3133765601 cites W1974254202 @default.
- W3133765601 cites W1974954833 @default.
- W3133765601 cites W1977013960 @default.
- W3133765601 cites W1977186288 @default.
- W3133765601 cites W1985563073 @default.
- W3133765601 cites W1995928801 @default.
- W3133765601 cites W1997483664 @default.
- W3133765601 cites W1998517969 @default.
- W3133765601 cites W2000156446 @default.
- W3133765601 cites W2010461414 @default.
- W3133765601 cites W2014522512 @default.
- W3133765601 cites W2017405165 @default.
- W3133765601 cites W2023304733 @default.
- W3133765601 cites W2026109069 @default.
- W3133765601 cites W2027963168 @default.
- W3133765601 cites W2029163015 @default.
- W3133765601 cites W2032114357 @default.
- W3133765601 cites W2033338665 @default.
- W3133765601 cites W2045113865 @default.
- W3133765601 cites W2050444114 @default.
- W3133765601 cites W2054499416 @default.
- W3133765601 cites W2069612491 @default.
- W3133765601 cites W2075329854 @default.
- W3133765601 cites W2077327925 @default.
- W3133765601 cites W2078249396 @default.
- W3133765601 cites W2082685557 @default.
- W3133765601 cites W2085123120 @default.
- W3133765601 cites W2093220633 @default.
- W3133765601 cites W2094097897 @default.
- W3133765601 cites W2096945157 @default.
- W3133765601 cites W2097120168 @default.
- W3133765601 cites W2097895380 @default.
- W3133765601 cites W2107669965 @default.
- W3133765601 cites W2108374688 @default.
- W3133765601 cites W2110233269 @default.
- W3133765601 cites W2112998032 @default.
- W3133765601 cites W2115819915 @default.
- W3133765601 cites W2119896120 @default.
- W3133765601 cites W2124985265 @default.
- W3133765601 cites W2127278504 @default.
- W3133765601 cites W2129820663 @default.
- W3133765601 cites W2132674062 @default.
- W3133765601 cites W2134756916 @default.
- W3133765601 cites W2143293793 @default.
- W3133765601 cites W2151299033 @default.
- W3133765601 cites W2151472648 @default.
- W3133765601 cites W2163672424 @default.
- W3133765601 cites W2179438025 @default.
- W3133765601 cites W2204827588 @default.
- W3133765601 cites W2283665483 @default.
- W3133765601 cites W2292210991 @default.
- W3133765601 cites W2317888977 @default.
- W3133765601 cites W2392898792 @default.
- W3133765601 cites W2416973816 @default.
- W3133765601 cites W2430283214 @default.
- W3133765601 cites W2501671555 @default.
- W3133765601 cites W2516349387 @default.
- W3133765601 cites W2533368663 @default.
- W3133765601 cites W2536558537 @default.
- W3133765601 cites W2556836201 @default.
- W3133765601 cites W2558211192 @default.
- W3133765601 cites W2559590288 @default.
- W3133765601 cites W2565259875 @default.
- W3133765601 cites W2582186503 @default.
- W3133765601 cites W2622756624 @default.
- W3133765601 cites W2757235462 @default.
- W3133765601 cites W2790139034 @default.
- W3133765601 cites W2792334910 @default.
- W3133765601 cites W2792485109 @default.
- W3133765601 cites W2806074626 @default.
- W3133765601 cites W2807180358 @default.
- W3133765601 cites W2808027513 @default.
- W3133765601 cites W2811212358 @default.
- W3133765601 cites W2883253665 @default.
- W3133765601 cites W2902165049 @default.