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- W3133768868 abstract "Cariogenic Streptococcus mutans is known as a predominant etiological agent of dental caries due to its exceptional capacity to form biofilms. From strains of S. mutans isolated from dental plaque, we discovered, in the present study, a polyketide/nonribosomal peptide biosynthetic gene cluster, muf, which directly correlates with a strong biofilm-forming capability. We then identified the muf-associated bioactive product, mutanofactin-697, which contains a new molecular scaffold, along with its biosynthetic logic. Further mode-of-action studies revealed that mutanofactin-697 binds to S. mutans cells and also extracellular DNA, increases bacterial hydrophobicity, and promotes bacterial adhesion and subsequent biofilm formation. Our findings provided an example of a microbial secondary metabolite promoting biofilm formation via a physicochemical approach, highlighting the importance of secondary metabolism in mediating critical processes related to the development of dental caries. The mutanofactin family of lipopeptide natural products, produced by strains of cariogenic Streptococcus mutans, promotes biofilm formation via increased cell-surface hydrophobicity and binding to extracellular DNA." @default.
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- W3133768868 date "2021-03-04" @default.
- W3133768868 modified "2023-10-11" @default.
- W3133768868 title "Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans" @default.
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- W3133768868 doi "https://doi.org/10.1038/s41589-021-00745-2" @default.
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