FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133777973> ?p ?o ?g. }

• W3133777973 abstract "Abstract Differentiation and proliferation of neural stem cells (NSCs) are both important biological processes in cerebral neural network. However, these two capacities of NSCs are limited. Thus, the induction of differentiation and/or proliferation via administration of small molecules derived from natural plants can be considered as a potential approach to repair damaged neural networks. This paper reports that gallic acid, a catechol compound selected from derivatives of methyl 3,4-dihydroxybenzoate (MDHB), selectively induces NSCs to differentiate into immature neurons and promotes proliferation by activating phosphorylation of key proteins in the MAPK-ERK pathway. In addition, we found that 3,4-dihydroxybenzoic acid was the main active structure which could show neurotrophic activity. The substitution of carboxyl group on the benzene ring into ester group may promote differentiation on the basis of the structure of 3,4-dihydroxybenzoic acid. Meanwhile, the introduction of 5-hydroxyl group may promote proliferation. Generally, this study identified a natural catechol compound that promotes differentiation and proliferation of NSCs in vitro." @default.
• W3133777973 created "2021-03-15" @default.
• W3133777973 creator A5009455568 @default.
• W3133777973 creator A5036195699 @default.
• W3133777973 creator A5044028571 @default.
• W3133777973 creator A5044688218 @default.
• W3133777973 creator A5047229351 @default.
• W3133777973 creator A5062919352 @default.
• W3133777973 creator A5065148547 @default.
• W3133777973 creator A5070472471 @default.
• W3133777973 creator A5071340346 @default.
• W3133777973 creator A5088702682 @default.
• W3133777973 creator A5089905331 @default.
• W3133777973 date "2021-03-02" @default.
• W3133777973 modified "2023-09-27" @default.
• W3133777973 title "Gallic Acid, a Methyl 3,4-Dihydroxybenzoate Derivative, Induces Neural Stem Cells to Differentiate and Proliferate" @default.
• W3133777973 cites W1555449469 @default.
• W3133777973 cites W1947629381 @default.
• W3133777973 cites W1988580558 @default.
• W3133777973 cites W2060583129 @default.
• W3133777973 cites W2081511893 @default.
• W3133777973 cites W2131150041 @default.
• W3133777973 cites W2165415169 @default.
• W3133777973 cites W2284794594 @default.
• W3133777973 cites W2291168073 @default.
• W3133777973 cites W2605442072 @default.
• W3133777973 cites W2769616494 @default.
• W3133777973 cites W2792867900 @default.
• W3133777973 cites W2803276543 @default.
• W3133777973 cites W2805290554 @default.
• W3133777973 cites W2807495567 @default.
• W3133777973 cites W2809528327 @default.
• W3133777973 cites W2905237107 @default.
• W3133777973 cites W2914974365 @default.
• W3133777973 cites W2927161771 @default.
• W3133777973 cites W2988231188 @default.
• W3133777973 cites W2992433300 @default.
• W3133777973 cites W2996201711 @default.
• W3133777973 cites W3128674731 @default.
• W3133777973 doi "https://doi.org/10.1101/2021.03.01.433474" @default.
• W3133777973 hasPublicationYear "2021" @default.
• W3133777973 type Work @default.
• W3133777973 sameAs 3133777973 @default.
• W3133777973 citedByCount "0" @default.
• W3133777973 crossrefType "posted-content" @default.
• W3133777973 hasAuthorship W3133777973A5009455568 @default.
• W3133777973 hasAuthorship W3133777973A5036195699 @default.
• W3133777973 hasAuthorship W3133777973A5044028571 @default.
• W3133777973 hasAuthorship W3133777973A5044688218 @default.
• W3133777973 hasAuthorship W3133777973A5047229351 @default.
• W3133777973 hasAuthorship W3133777973A5062919352 @default.
• W3133777973 hasAuthorship W3133777973A5065148547 @default.
• W3133777973 hasAuthorship W3133777973A5070472471 @default.
• W3133777973 hasAuthorship W3133777973A5071340346 @default.
• W3133777973 hasAuthorship W3133777973A5088702682 @default.
• W3133777973 hasAuthorship W3133777973A5089905331 @default.
• W3133777973 hasBestOaLocation W31337779731 @default.
• W3133777973 hasConcept C113246987 @default.
• W3133777973 hasConcept C11960822 @default.
• W3133777973 hasConcept C136834591 @default.
• W3133777973 hasConcept C160539049 @default.
• W3133777973 hasConcept C170493617 @default.
• W3133777973 hasConcept C185592680 @default.
• W3133777973 hasConcept C202751555 @default.
• W3133777973 hasConcept C2777713698 @default.
• W3133777973 hasConcept C2778004101 @default.
• W3133777973 hasConcept C2778362808 @default.
• W3133777973 hasConcept C28328180 @default.
• W3133777973 hasConcept C55493867 @default.
• W3133777973 hasConcept C57074206 @default.
• W3133777973 hasConcept C86803240 @default.
• W3133777973 hasConcept C95444343 @default.
• W3133777973 hasConceptScore W3133777973C113246987 @default.
• W3133777973 hasConceptScore W3133777973C11960822 @default.
• W3133777973 hasConceptScore W3133777973C136834591 @default.
• W3133777973 hasConceptScore W3133777973C160539049 @default.
• W3133777973 hasConceptScore W3133777973C170493617 @default.
• W3133777973 hasConceptScore W3133777973C185592680 @default.
• W3133777973 hasConceptScore W3133777973C202751555 @default.
• W3133777973 hasConceptScore W3133777973C2777713698 @default.
• W3133777973 hasConceptScore W3133777973C2778004101 @default.
• W3133777973 hasConceptScore W3133777973C2778362808 @default.
• W3133777973 hasConceptScore W3133777973C28328180 @default.
• W3133777973 hasConceptScore W3133777973C55493867 @default.
• W3133777973 hasConceptScore W3133777973C57074206 @default.
• W3133777973 hasConceptScore W3133777973C86803240 @default.
• W3133777973 hasConceptScore W3133777973C95444343 @default.
• W3133777973 hasLocation W31337779731 @default.
• W3133777973 hasOpenAccess W3133777973 @default.
• W3133777973 hasPrimaryLocation W31337779731 @default.
• W3133777973 hasRelatedWork W10381082 @default.
• W3133777973 hasRelatedWork W10410406 @default.
• W3133777973 hasRelatedWork W12464845 @default.
• W3133777973 hasRelatedWork W13886991 @default.
• W3133777973 hasRelatedWork W15856673 @default.
• W3133777973 hasRelatedWork W17284295 @default.
• W3133777973 hasRelatedWork W3409586 @default.
• W3133777973 hasRelatedWork W8645026 @default.
• W3133777973 hasRelatedWork W8734676 @default.
• W3133777973 hasRelatedWork W9262949 @default.

• next