FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133794564> ?p ?o ?g. }

• W3133794564 endingPage "15" @default.
• W3133794564 startingPage "1" @default.
• W3133794564 abstract "DUOX2 has been reported to highly express in several types of cancers. However, the prognostic significance and the biological function of DUOX2 expression with pancreatic cancer (PC) still remain unclear. The present study is aimed at investigating whether DUOX2 could act as a novel biomarker of prognosis and evaluating its effect on PC cell progression. The mRNA and protein expression of DUOX2 in PC cells and tissues were assessed by quantitative real-time PCR (RT-qPCR) and immunohistochemistry. The effect of DUOX2 expression on PC cell motility and proliferation was evaluated in vitro. The correlation between DUOX2 mRNA expression and clinicopathological features and its prognostic significance were analyzed according to the Gene Expression Profiling Interactive Analysis (GEPIA) website based on The Cancer Genome Atlas (TCGA) and the GTEx databases combined with our clinical information. According to bioinformatics analysis, we forecasted the upstream transcription factors (TFs) and microRNA (miRNA) regulatory mechanism of DUOX2 in PC. The expression of DUOX2 at transcriptional and protein level was dramatically increased in PC specimens when compared to adjacent nontumor specimens. Functionally, DUOX2 knockdown inhibited cell motility and proliferation activities. Our clinical data revealed that the patients had better postoperative overall survival (OS) with lower expression of DUOX2, which is consistent with GEPIA data. Multivariate analysis revealed that high DUOX2 expression was considered as an independent prognostic indicator for OS ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>P</mi> <mo>=</mo> <mn>0.031</mn> </math> ). Based on Cistrome database, the top 5 TFs of each positively and negatively association with DUOX2 were predicted. hsa-miR-5193 and hsa-miR-1343-3p targeting DUOX2 were forecasted from TargetScan, miRDB, and DIANA-TarBase databases, which were negatively correlated with OS ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>P</mi> <mo>=</mo> <mn>0.043</mn> </math> and <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>P</mi> <mo>=</mo> <mn>0.0088</mn> </math> , respectively) and DUOX2 expression ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>P</mi> <mo>=</mo> <mn>0.0093</mn> </math> and <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>P</mi> <mo>=</mo> <mn>0.0032</mn> </math> , respectively) in PC from TCGA data. These findings suggest that DUOX2 acts as a promising predictive biomarker and an oncogene in PC, which could be a therapeutic target for PC." @default.
• W3133794564 created "2021-03-15" @default.
• W3133794564 creator A5012571820 @default.
• W3133794564 creator A5027392261 @default.
• W3133794564 creator A5030498698 @default.
• W3133794564 creator A5035175414 @default.
• W3133794564 creator A5040585791 @default.
• W3133794564 creator A5041048323 @default.
• W3133794564 creator A5041610421 @default.
• W3133794564 creator A5055761155 @default.
• W3133794564 creator A5056061530 @default.
• W3133794564 creator A5063476562 @default.
• W3133794564 date "2021-03-02" @default.
• W3133794564 modified "2023-10-16" @default.
• W3133794564 title "DUOX2 As a Potential Prognostic Marker which Promotes Cell Motility and Proliferation in Pancreatic Cancer" @default.
• W3133794564 cites W1757407923 @default.
• W3133794564 cites W1965613536 @default.
• W3133794564 cites W1985213644 @default.
• W3133794564 cites W2023007676 @default.
• W3133794564 cites W2029863885 @default.
• W3133794564 cites W2031806370 @default.
• W3133794564 cites W2085128107 @default.
• W3133794564 cites W2112610954 @default.
• W3133794564 cites W2115663098 @default.
• W3133794564 cites W2122663828 @default.
• W3133794564 cites W2136159290 @default.
• W3133794564 cites W2144186997 @default.
• W3133794564 cites W2160391606 @default.
• W3133794564 cites W2183130259 @default.
• W3133794564 cites W2257647300 @default.
• W3133794564 cites W2275127695 @default.
• W3133794564 cites W2431784490 @default.
• W3133794564 cites W2519498784 @default.
• W3133794564 cites W2598266532 @default.
• W3133794564 cites W2607129810 @default.
• W3133794564 cites W2754510647 @default.
• W3133794564 cites W2755159617 @default.
• W3133794564 cites W2761649749 @default.
• W3133794564 cites W2768632638 @default.
• W3133794564 cites W2772589982 @default.
• W3133794564 cites W2792142773 @default.
• W3133794564 cites W2792797937 @default.
• W3133794564 cites W2897058279 @default.
• W3133794564 cites W2899673882 @default.
• W3133794564 cites W2901027836 @default.
• W3133794564 cites W2901102887 @default.
• W3133794564 cites W2903360508 @default.
• W3133794564 cites W2904244760 @default.
• W3133794564 cites W2907207934 @default.
• W3133794564 cites W2908593015 @default.
• W3133794564 cites W2917648886 @default.
• W3133794564 cites W2932498431 @default.
• W3133794564 cites W2935703039 @default.
• W3133794564 cites W2953730417 @default.
• W3133794564 cites W2970358232 @default.
• W3133794564 cites W2975913332 @default.
• W3133794564 cites W2989516825 @default.
• W3133794564 cites W2991545900 @default.
• W3133794564 cites W2998833242 @default.
• W3133794564 cites W3003380927 @default.
• W3133794564 cites W3004120799 @default.
• W3133794564 cites W3038237623 @default.
• W3133794564 doi "https://doi.org/10.1155/2021/6530298" @default.
• W3133794564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7943273" @default.
• W3133794564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33748270" @default.
• W3133794564 hasPublicationYear "2021" @default.
• W3133794564 type Work @default.
• W3133794564 sameAs 3133794564 @default.
• W3133794564 citedByCount "3" @default.
• W3133794564 countsByYear W31337945642022 @default.
• W3133794564 countsByYear W31337945642023 @default.
• W3133794564 crossrefType "journal-article" @default.
• W3133794564 hasAuthorship W3133794564A5012571820 @default.
• W3133794564 hasAuthorship W3133794564A5027392261 @default.
• W3133794564 hasAuthorship W3133794564A5030498698 @default.
• W3133794564 hasAuthorship W3133794564A5035175414 @default.
• W3133794564 hasAuthorship W3133794564A5040585791 @default.
• W3133794564 hasAuthorship W3133794564A5041048323 @default.
• W3133794564 hasAuthorship W3133794564A5041610421 @default.
• W3133794564 hasAuthorship W3133794564A5055761155 @default.
• W3133794564 hasAuthorship W3133794564A5056061530 @default.
• W3133794564 hasAuthorship W3133794564A5063476562 @default.
• W3133794564 hasBestOaLocation W31337945641 @default.
• W3133794564 hasConcept C104317684 @default.
• W3133794564 hasConcept C105580179 @default.
• W3133794564 hasConcept C121608353 @default.
• W3133794564 hasConcept C126322002 @default.
• W3133794564 hasConcept C143998085 @default.
• W3133794564 hasConcept C145059251 @default.
• W3133794564 hasConcept C1491633281 @default.
• W3133794564 hasConcept C158163496 @default.
• W3133794564 hasConcept C173396325 @default.
• W3133794564 hasConcept C203014093 @default.
• W3133794564 hasConcept C204232928 @default.
• W3133794564 hasConcept C2780210213 @default.
• W3133794564 hasConcept C2781197716 @default.
• W3133794564 hasConcept C502942594 @default.
• W3133794564 hasConcept C54355233 @default.

• next