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- W3133796281 endingPage "520" @default.
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- W3133796281 abstract "Abstract The discovery of Langerhans and microscopic description of islets in the pancreas were crucial steps in the discovery of insulin. Over the past 150 years, many discoveries in islet biology and type 1 diabetes have been made using powerful microscopic techniques. In the past decade, combination of new probes, animal and tissue models, application of new biosensors and automation of light and electron microscopic methods and other (sub)cellular imaging modalities have proven their potential in understanding the beta cell under (patho)physiological conditions. The imaging evolution, from fluorescent jellyfish to real‐time intravital functional imaging, the revolution in automation and data handling and the increased resolving power of analytical imaging techniques are now converging. Here, we review innovative approaches that address islet biology from new angles by studying cells and molecules at high spatiotemporal resolution and in live models. Broad implementation of these cellular imaging techniques will shed new light on cause/consequence of (mal)function in islets of Langerhans in the years to come." @default.
- W3133796281 created "2021-03-15" @default.
- W3133796281 creator A5007457713 @default.
- W3133796281 creator A5044120923 @default.
- W3133796281 date "2021-05-01" @default.
- W3133796281 modified "2023-10-18" @default.
- W3133796281 title "State‐of‐the‐art microscopy to understand islets of Langerhans: what to expect next?" @default.
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- W3133796281 doi "https://doi.org/10.1111/imcb.12450" @default.
- W3133796281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8252556" @default.
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- W3133796281 hasPublicationYear "2021" @default.
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