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- W3133808912 abstract "Abstract The dopamine transporter (DAT) transports extracellular dopamine into the intracellular space contributing to the regulation of dopamine neurotransmission. A reduction of DAT density is implicated in Parkinson’s disease (PD) by neuroimaging; dopamine turnover is dopamine turnover is elevated in early symptomatic PD and in presymptomatic individuals with monogenic mutations causal for parkinsonism. As an integral plasma membrane protein, DAT surface expression is dynamically regulated through endocytic trafficking, enabling flexible control of dopamine signaling in time and space, which in turn critically modulates movement, motivation and learning behavior. Yet the cellular machinery and functional implications of DAT trafficking remain enigmatic. In this review we summarize mechanisms governing DAT trafficking under normal physiological conditions and discuss how PD-linked mutations may disturb DAT homeostasis. We highlight the complexity of DAT trafficking and reveal DAT dysregulation as a common theme in genetic models of parkinsonism." @default.
- W3133808912 created "2021-03-15" @default.
- W3133808912 creator A5008899169 @default.
- W3133808912 creator A5014974468 @default.
- W3133808912 creator A5048711837 @default.
- W3133808912 date "2021-03-05" @default.
- W3133808912 modified "2023-10-15" @default.
- W3133808912 title "Dynamic control of the dopamine transporter in neurotransmission and homeostasis" @default.
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