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- W3133818968 abstract "Prostate cancer (PCa) is the second-most common cancer in men worldwide and treatment options for patients with advanced or aggressive prostate cancer or recurrent disease continue to be of limited success and are rarely curative. Despite immune checkpoint blockade (ICB) efficacy in some melanoma, lung, kidney and breast cancers, immunotherapy efforts have been remarkably unsuccessful in PCa. One hypothesis behind this lack of efficacy is the generation of a distinctly immunosuppressive prostate tumor microenvironment (TME) by regulatory T cells, MDSCs, and type 2 macrophages which have been implicated in a variety of pathological conditions including solid cancers. In PCa, Tregs and MDSCs are attracted to TME by low-grade chronic inflammatory signals, while tissue-resident type 2 macrophages are induced by cytokines such as IL4, IL10, IL13, transforming growth factor beta (TGFβ) or prostaglandin E2 (PGE2) produced by Th2 cells. These then drive tumor progression, therapy resistance and the generation of castration resistance, ultimately conferring a poor prognosis. The biology of MDSC and Treg is highly complex and the development, proliferation, maturation or function can each be pharmacologically mediated to counteract the immunosuppressive effects of these cells. Herein, we present a critical review of Treg, MDSC and M2 involvement in PCa progression but also investigate a newly recognized type of immune suppression induced by the chronic stimulation of the sympathetic adrenergic signaling pathway and propose targeted strategies to be used in a combinatorial modality with immunotherapy interventions such as ICB, Sipuleucel-T or antitumor vaccines for an enhanced anti-PCa tumor immune response. We conclude that a strategic sequence of therapeutic interventions in combination with additional holistic measures will be necessary to achieve maximum benefit for PCa patients." @default.
- W3133818968 created "2021-03-15" @default.
- W3133818968 creator A5003287905 @default.
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- W3133818968 creator A5057129908 @default.
- W3133818968 creator A5073567520 @default.
- W3133818968 date "2021-03-08" @default.
- W3133818968 modified "2023-09-26" @default.
- W3133818968 title "Novel Combinatorial Approaches to Tackle the Immunosuppressive Microenvironment of Prostate Cancer" @default.
- W3133818968 cites W1487307409 @default.
- W3133818968 cites W1520988368 @default.
- W3133818968 cites W1535497156 @default.
- W3133818968 cites W1550830253 @default.
- W3133818968 cites W1552212814 @default.
- W3133818968 cites W1712093107 @default.
- W3133818968 cites W1766785937 @default.
- W3133818968 cites W1828843046 @default.
- W3133818968 cites W1918811259 @default.
- W3133818968 cites W1933912253 @default.
- W3133818968 cites W1955759569 @default.
- W3133818968 cites W1967979334 @default.
- W3133818968 cites W1973004518 @default.
- W3133818968 cites W1973588440 @default.
- W3133818968 cites W1973601490 @default.
- W3133818968 cites W1979811833 @default.
- W3133818968 cites W1980626135 @default.
- W3133818968 cites W1982488143 @default.
- W3133818968 cites W1984127028 @default.
- W3133818968 cites W1989403098 @default.
- W3133818968 cites W1990317839 @default.
- W3133818968 cites W1992443284 @default.
- W3133818968 cites W1993340690 @default.
- W3133818968 cites W1995232616 @default.
- W3133818968 cites W1996998764 @default.
- W3133818968 cites W1997154923 @default.
- W3133818968 cites W1998635761 @default.
- W3133818968 cites W2004445332 @default.
- W3133818968 cites W2009423208 @default.
- W3133818968 cites W2010735105 @default.
- W3133818968 cites W2013099477 @default.
- W3133818968 cites W2018050275 @default.
- W3133818968 cites W2026624128 @default.
- W3133818968 cites W2031200699 @default.
- W3133818968 cites W2032268859 @default.
- W3133818968 cites W2039139796 @default.
- W3133818968 cites W2041956823 @default.
- W3133818968 cites W2046768931 @default.
- W3133818968 cites W2048813174 @default.
- W3133818968 cites W2049959255 @default.
- W3133818968 cites W2054829361 @default.
- W3133818968 cites W2066221156 @default.
- W3133818968 cites W2069116711 @default.
- W3133818968 cites W2077773656 @default.
- W3133818968 cites W2079068389 @default.
- W3133818968 cites W2081748846 @default.
- W3133818968 cites W2084893501 @default.
- W3133818968 cites W2088231330 @default.
- W3133818968 cites W2092324684 @default.
- W3133818968 cites W2094190365 @default.
- W3133818968 cites W2094211489 @default.
- W3133818968 cites W2095284457 @default.
- W3133818968 cites W2096693293 @default.
- W3133818968 cites W2098104000 @default.
- W3133818968 cites W2103959341 @default.
- W3133818968 cites W2104065243 @default.
- W3133818968 cites W210558271 @default.
- W3133818968 cites W2108382474 @default.
- W3133818968 cites W2110569728 @default.
- W3133818968 cites W2112588641 @default.
- W3133818968 cites W2118173250 @default.
- W3133818968 cites W2119734380 @default.
- W3133818968 cites W2123073309 @default.
- W3133818968 cites W2123526148 @default.
- W3133818968 cites W2125110063 @default.
- W3133818968 cites W2126503106 @default.
- W3133818968 cites W2128957395 @default.
- W3133818968 cites W2132108367 @default.
- W3133818968 cites W2136798443 @default.
- W3133818968 cites W2140687262 @default.
- W3133818968 cites W2141454098 @default.
- W3133818968 cites W2147984855 @default.
- W3133818968 cites W2149360266 @default.
- W3133818968 cites W2149379768 @default.
- W3133818968 cites W2149570955 @default.
- W3133818968 cites W2151087797 @default.
- W3133818968 cites W2153232526 @default.
- W3133818968 cites W2159038842 @default.
- W3133818968 cites W2159810380 @default.
- W3133818968 cites W2160245658 @default.
- W3133818968 cites W2160516412 @default.
- W3133818968 cites W2160834915 @default.
- W3133818968 cites W2165064029 @default.
- W3133818968 cites W2166406775 @default.
- W3133818968 cites W2169391650 @default.
- W3133818968 cites W2170390714 @default.
- W3133818968 cites W2170805832 @default.
- W3133818968 cites W2171365282 @default.