FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133839902> ?p ?o ?g. }

• W3133839902 endingPage "101912" @default.
• W3133839902 startingPage "101912" @default.
• W3133839902 abstract "The obesity paradox, whereby obesity appears to confer protection against cancer-related mortality, remains controversial. This has not yet been evaluated in upper gastrointestinal cancers.We identified esophageal, cardia, and non-cardia gastric adenocarcinomas in the Veterans Health Administration between 2006-2016. Multivariable Cox proportional hazard models evaluate the impact of BMI at- and prior to- cancer diagnosis on mortality, adjusting for demographics, clinical characteristics, weight loss, and clinical stage (early: T1B/2N0; locally advanced: ≥T2N+).We identify 1308 patients: 99 % male, median 66 years. In early disease, relative to BMI 30, BMI 18 and 20 at diagnosis had increased risk of death (HR 1.83, 95 %CI: 1.38-2.44 and HR 1.50, 95 %CI: 1.20-1.87, respectively, p < 0.0001). Patients with BMI > 30 did not. In locally advanced disease, at diagnosis BMI 18 (HR 1.58, 95 %CI: 1.0001-1.48, p = 0.05), BMI 20 (HR 1.46, 95 %CI: 1.01-2.09, p = 0.04), and BMI 25 (HR 1.20, 95 %CI: 1.04-1.38, p = 0.01) had increased risk of death, but BMI > 30 did not. In models assessing premorbid BMI and weight loss, increasing amounts of weight loss were associated with mortality independent of BMI in early cancers. For locally advanced cancers, without weight loss, there was no association with death, regardless of BMI.The predominant driver of mortality across clinical stages is weight loss. The obesity paradox appears to exist in early stage disease only. Future studies should investigate mechanisms for the obesity paradox, accompanying physiologic changes with weight loss preceding diagnosis, and if patients with low BMI and weight loss benefit from early nutritional support." @default.
• W3133839902 created "2021-03-15" @default.
• W3133839902 creator A5001060160 @default.
• W3133839902 creator A5004110157 @default.
• W3133839902 creator A5058696857 @default.
• W3133839902 creator A5065401142 @default.
• W3133839902 creator A5081723300 @default.
• W3133839902 date "2021-06-01" @default.
• W3133839902 modified "2023-09-23" @default.
• W3133839902 title "Disentangling the obesity paradox in upper gastrointestinal cancers: Weight loss matters more than body mass index" @default.
• W3133839902 cites W1204190333 @default.
• W3133839902 cites W1540326067 @default.
• W3133839902 cites W1547708675 @default.
• W3133839902 cites W1845104273 @default.
• W3133839902 cites W1968020758 @default.
• W3133839902 cites W1974423646 @default.
• W3133839902 cites W1975604425 @default.
• W3133839902 cites W1985442568 @default.
• W3133839902 cites W1991502675 @default.
• W3133839902 cites W1993467048 @default.
• W3133839902 cites W2031808191 @default.
• W3133839902 cites W2038623844 @default.
• W3133839902 cites W2046387692 @default.
• W3133839902 cites W2059419158 @default.
• W3133839902 cites W2068622355 @default.
• W3133839902 cites W2087177011 @default.
• W3133839902 cites W2088576528 @default.
• W3133839902 cites W2092367583 @default.
• W3133839902 cites W2096118388 @default.
• W3133839902 cites W2105746949 @default.
• W3133839902 cites W2110139358 @default.
• W3133839902 cites W2118832599 @default.
• W3133839902 cites W2121406067 @default.
• W3133839902 cites W2128758643 @default.
• W3133839902 cites W2136806333 @default.
• W3133839902 cites W2166680092 @default.
• W3133839902 cites W2279237160 @default.
• W3133839902 cites W2311414532 @default.
• W3133839902 cites W2395076114 @default.
• W3133839902 cites W2482556255 @default.
• W3133839902 cites W2510411424 @default.
• W3133839902 cites W2518082324 @default.
• W3133839902 cites W2527602327 @default.
• W3133839902 cites W2551296486 @default.
• W3133839902 cites W2552504817 @default.
• W3133839902 cites W2570629783 @default.
• W3133839902 cites W2597452751 @default.
• W3133839902 cites W2617230837 @default.
• W3133839902 cites W2730542268 @default.
• W3133839902 cites W2788924817 @default.
• W3133839902 cites W2794311213 @default.
• W3133839902 cites W2802067770 @default.
• W3133839902 cites W2809597231 @default.
• W3133839902 cites W2969478687 @default.
• W3133839902 cites W2975633737 @default.
• W3133839902 cites W2982207174 @default.
• W3133839902 cites W3000376411 @default.
• W3133839902 cites W3005705986 @default.
• W3133839902 doi "https://doi.org/10.1016/j.canep.2021.101912" @default.
• W3133839902 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8141012" @default.
• W3133839902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33647837" @default.
• W3133839902 hasPublicationYear "2021" @default.
• W3133839902 type Work @default.
• W3133839902 sameAs 3133839902 @default.
• W3133839902 citedByCount "3" @default.
• W3133839902 countsByYear W31338399022021 @default.
• W3133839902 countsByYear W31338399022022 @default.
• W3133839902 countsByYear W31338399022023 @default.
• W3133839902 crossrefType "journal-article" @default.
• W3133839902 hasAuthorship W3133839902A5001060160 @default.
• W3133839902 hasAuthorship W3133839902A5004110157 @default.
• W3133839902 hasAuthorship W3133839902A5058696857 @default.
• W3133839902 hasAuthorship W3133839902A5065401142 @default.
• W3133839902 hasAuthorship W3133839902A5081723300 @default.
• W3133839902 hasBestOaLocation W31338399022 @default.
• W3133839902 hasConcept C121608353 @default.
• W3133839902 hasConcept C126322002 @default.
• W3133839902 hasConcept C207103383 @default.
• W3133839902 hasConcept C2779134260 @default.
• W3133839902 hasConcept C2780221984 @default.
• W3133839902 hasConcept C2780586474 @default.
• W3133839902 hasConcept C2781223611 @default.
• W3133839902 hasConcept C3017894415 @default.
• W3133839902 hasConcept C44249647 @default.
• W3133839902 hasConcept C50382708 @default.
• W3133839902 hasConcept C511355011 @default.
• W3133839902 hasConcept C544821477 @default.
• W3133839902 hasConcept C71924100 @default.
• W3133839902 hasConcept C90924648 @default.
• W3133839902 hasConceptScore W3133839902C121608353 @default.
• W3133839902 hasConceptScore W3133839902C126322002 @default.
• W3133839902 hasConceptScore W3133839902C207103383 @default.
• W3133839902 hasConceptScore W3133839902C2779134260 @default.
• W3133839902 hasConceptScore W3133839902C2780221984 @default.
• W3133839902 hasConceptScore W3133839902C2780586474 @default.
• W3133839902 hasConceptScore W3133839902C2781223611 @default.
• W3133839902 hasConceptScore W3133839902C3017894415 @default.
• W3133839902 hasConceptScore W3133839902C44249647 @default.

• next