Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133884234> ?p ?o ?g. }
- W3133884234 endingPage "e0248190" @default.
- W3133884234 startingPage "e0248190" @default.
- W3133884234 abstract "Muramidases/lysozymes hydrolyse the peptidoglycan component of the bacterial cell wall. They are found in many of the glycoside hydrolase (GH) families. Family GH25 contains muramidases/lysozymes, known as CH type lysozymes, as they were initially discovered in the Chalaropsis species of fungus. The characterized enzymes from GH25 exhibit both β-1,4-N-acetyl- and β-1,4-N,6-O-diacetylmuramidase activities, cleaving the β-1,4-glycosidic bond between N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) moieties in the carbohydrate backbone of bacterial peptidoglycan. Here, a set of fungal GH25 muramidases were identified from a sequence search, cloned and expressed and screened for their ability to digest bacterial peptidoglycan, to be used in a commercial application in chicken feed. The screen identified the enzyme from Acremonium alcalophilum JCM 736 as a suitable candidate for this purpose and its relevant biochemical and biophysical and properties are described. We report the crystal structure of the A. alcalophilum enzyme at atomic, 0.78 Å resolution, together with that of its homologue from Trichobolus zukalii at 1.4 Å, and compare these with the structures of homologues. GH25 enzymes offer a new solution in animal feed applications such as for processing bacterial debris in the animal gut." @default.
- W3133884234 created "2021-03-15" @default.
- W3133884234 creator A5002424558 @default.
- W3133884234 creator A5009478169 @default.
- W3133884234 creator A5010963202 @default.
- W3133884234 creator A5013878133 @default.
- W3133884234 creator A5018742393 @default.
- W3133884234 creator A5024647487 @default.
- W3133884234 creator A5039889042 @default.
- W3133884234 creator A5041541957 @default.
- W3133884234 creator A5043738491 @default.
- W3133884234 creator A5050206091 @default.
- W3133884234 creator A5054127929 @default.
- W3133884234 creator A5056600509 @default.
- W3133884234 creator A5060422465 @default.
- W3133884234 creator A5070540085 @default.
- W3133884234 creator A5084814667 @default.
- W3133884234 date "2021-03-12" @default.
- W3133884234 modified "2023-10-16" @default.
- W3133884234 title "Fungal GH25 muramidases: New family members with applications in animal nutrition and a crystal structure at 0.78Å resolution" @default.
- W3133884234 cites W1494947540 @default.
- W3133884234 cites W1594413942 @default.
- W3133884234 cites W1595134841 @default.
- W3133884234 cites W1660246127 @default.
- W3133884234 cites W1877330098 @default.
- W3133884234 cites W1892158199 @default.
- W3133884234 cites W1977450486 @default.
- W3133884234 cites W1978096114 @default.
- W3133884234 cites W1981232704 @default.
- W3133884234 cites W2002219905 @default.
- W3133884234 cites W2003215982 @default.
- W3133884234 cites W2021120199 @default.
- W3133884234 cites W2039206746 @default.
- W3133884234 cites W2042217887 @default.
- W3133884234 cites W2044825931 @default.
- W3133884234 cites W2048640675 @default.
- W3133884234 cites W2049483740 @default.
- W3133884234 cites W2062748780 @default.
- W3133884234 cites W2070380466 @default.
- W3133884234 cites W2091404655 @default.
- W3133884234 cites W2095237995 @default.
- W3133884234 cites W2106325630 @default.
- W3133884234 cites W2108921801 @default.
- W3133884234 cites W2110808180 @default.
- W3133884234 cites W2121704271 @default.
- W3133884234 cites W2122559203 @default.
- W3133884234 cites W2123922992 @default.
- W3133884234 cites W2127467087 @default.
- W3133884234 cites W2144081223 @default.
- W3133884234 cites W2144998676 @default.
- W3133884234 cites W2146080841 @default.
- W3133884234 cites W2149941565 @default.
- W3133884234 cites W2154714625 @default.
- W3133884234 cites W2159211495 @default.
- W3133884234 cites W2164382089 @default.
- W3133884234 cites W2168974130 @default.
- W3133884234 cites W2170628857 @default.
- W3133884234 cites W2195878577 @default.
- W3133884234 cites W2500767364 @default.
- W3133884234 cites W2512083312 @default.
- W3133884234 cites W2735721896 @default.
- W3133884234 cites W2793778456 @default.
- W3133884234 cites W2806303726 @default.
- W3133884234 cites W2811039480 @default.
- W3133884234 cites W2904273418 @default.
- W3133884234 cites W2968037125 @default.
- W3133884234 cites W2986884981 @default.
- W3133884234 cites W4248872320 @default.
- W3133884234 cites W84170190 @default.
- W3133884234 doi "https://doi.org/10.1371/journal.pone.0248190" @default.
- W3133884234 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7954357" @default.
- W3133884234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33711051" @default.
- W3133884234 hasPublicationYear "2021" @default.
- W3133884234 type Work @default.
- W3133884234 sameAs 3133884234 @default.
- W3133884234 citedByCount "3" @default.
- W3133884234 countsByYear W31338842342022 @default.
- W3133884234 countsByYear W31338842342023 @default.
- W3133884234 crossrefType "journal-article" @default.
- W3133884234 hasAuthorship W3133884234A5002424558 @default.
- W3133884234 hasAuthorship W3133884234A5009478169 @default.
- W3133884234 hasAuthorship W3133884234A5010963202 @default.
- W3133884234 hasAuthorship W3133884234A5013878133 @default.
- W3133884234 hasAuthorship W3133884234A5018742393 @default.
- W3133884234 hasAuthorship W3133884234A5024647487 @default.
- W3133884234 hasAuthorship W3133884234A5039889042 @default.
- W3133884234 hasAuthorship W3133884234A5041541957 @default.
- W3133884234 hasAuthorship W3133884234A5043738491 @default.
- W3133884234 hasAuthorship W3133884234A5050206091 @default.
- W3133884234 hasAuthorship W3133884234A5054127929 @default.
- W3133884234 hasAuthorship W3133884234A5056600509 @default.
- W3133884234 hasAuthorship W3133884234A5060422465 @default.
- W3133884234 hasAuthorship W3133884234A5070540085 @default.
- W3133884234 hasAuthorship W3133884234A5084814667 @default.
- W3133884234 hasBestOaLocation W31338842341 @default.
- W3133884234 hasConcept C125235067 @default.
- W3133884234 hasConcept C150487720 @default.
- W3133884234 hasConcept C181199279 @default.