Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133909171> ?p ?o ?g. }
- W3133909171 endingPage "108523" @default.
- W3133909171 startingPage "108523" @default.
- W3133909171 abstract "Dry eye syndrome (DES) and tear dysfunction are multifactorial conditions affecting meibomian glands, lacrimal glands, and ocular surface. This ocular disorder can cause eye irritation, irregular cornea, corneal barrier disruption, and blurred vision. Uncontrolled increase in matrix metalloproteinase-9 (MMP-9) level and activity has been detected in the tears and ocular surface in the patients with DES, which has been proved to be related to disruption of tight junctions in apical corneal epithelium associated with severe signs of DES. These uncontrolled activities of MMP-9 lead to desquamation of ocular surface epithelia. Therefore, this review study was conducted to summarize the evidence regarding MMP-9 contribution in DES, and inhibition of MMP-9, as a therapeutic target for treatment of DES. For this purpose, herein, the related studies designed novel pharmaceutical compounds for direct and indirect inhibition of MMP-9 as treatment approaches for DES were reviewed. These compounds were designed to improve corneal barrier function, reduce inflammation on ocular surface, and restore tear production." @default.
- W3133909171 created "2021-03-15" @default.
- W3133909171 creator A5017262589 @default.
- W3133909171 creator A5035218785 @default.
- W3133909171 creator A5080421221 @default.
- W3133909171 date "2021-04-01" @default.
- W3133909171 modified "2023-09-26" @default.
- W3133909171 title "Inhibition of matrix metalloproteinase-9 for the treatment of dry eye syndrome; a review study" @default.
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