FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133951171> ?p ?o ?g. }

• W3133951171 endingPage "57" @default.
• W3133951171 startingPage "49" @default.
• W3133951171 abstract "We performed clinical retrospective study in female cancer patients and fundamental experiments in mice, in order to clarify risk factors for paclitaxel-induced peripheral neuropathy (PIPN). In the clinical study, 131 of 189 female outpatients with cancer undergoing paclitaxel-based chemotherapy met inclusion criteria. Breast cancer survivors (n = 40) showed significantly higher overall PIPN (grades 1–4) incidence than non-breast cancer survivors (n = 91). Multivariate sub-analyses of breast cancer survivors showed that 57 years of age or older and endocrine therapy before paclitaxel treatment were significantly associated with severe PIPN (grades 2–4). The age limit was also significantly correlated with overall development of severe PIPN. In the preclinical study, female mice subjected to ovariectomy received repeated administration of paclitaxel, and mechanical nociceptive threshold was assessed by von Frey test. Ovariectomy aggravated PIPN in the mice, an effect prevented by repeated treatment with 17β-estradiol. Repeated administration of thrombomodulin alfa (TMα), known to prevent chemotherapy-induced peripheral neuropathy in rats and mice, also prevented the development of PIPN in the ovariectomized mice. Collectively, breast cancer survivors, particularly with postmenopausal estrogen decline and/or undergoing endocrine therapy, are considered a PIPN-prone subpopulation, and may require non-hormonal pharmacological intervention for PIPN in which TMα may serve as a major candidate." @default.
• W3133951171 created "2021-03-15" @default.
• W3133951171 creator A5026511895 @default.
• W3133951171 creator A5030587024 @default.
• W3133951171 creator A5031334106 @default.
• W3133951171 creator A5035020827 @default.
• W3133951171 creator A5037553054 @default.
• W3133951171 creator A5054907762 @default.
• W3133951171 creator A5062528334 @default.
• W3133951171 creator A5071654647 @default.
• W3133951171 creator A5075514275 @default.
• W3133951171 creator A5088676109 @default.
• W3133951171 date "2021-05-01" @default.
• W3133951171 modified "2023-09-25" @default.
• W3133951171 title "Estrogen decline is a risk factor for paclitaxel-induced peripheral neuropathy: Clinical evidence supported by a preclinical study" @default.
• W3133951171 cites W1555027298 @default.
• W3133951171 cites W1759257429 @default.
• W3133951171 cites W1974318755 @default.
• W3133951171 cites W1978055756 @default.
• W3133951171 cites W2009110883 @default.
• W3133951171 cites W2009535818 @default.
• W3133951171 cites W2009747539 @default.
• W3133951171 cites W2018452033 @default.
• W3133951171 cites W2021347163 @default.
• W3133951171 cites W2060140468 @default.
• W3133951171 cites W2092106307 @default.
• W3133951171 cites W2114458368 @default.
• W3133951171 cites W2123543192 @default.
• W3133951171 cites W2126970578 @default.
• W3133951171 cites W2166455594 @default.
• W3133951171 cites W2169311890 @default.
• W3133951171 cites W2471488931 @default.
• W3133951171 cites W2493266198 @default.
• W3133951171 cites W2494659121 @default.
• W3133951171 cites W2740355842 @default.
• W3133951171 cites W2750084680 @default.
• W3133951171 cites W2750983142 @default.
• W3133951171 cites W2768996399 @default.
• W3133951171 cites W2769882218 @default.
• W3133951171 cites W2775694620 @default.
• W3133951171 cites W2888801541 @default.
• W3133951171 cites W2902857460 @default.
• W3133951171 cites W2905515070 @default.
• W3133951171 cites W2944612900 @default.
• W3133951171 cites W2945906258 @default.
• W3133951171 cites W2982503761 @default.
• W3133951171 cites W2989310232 @default.
• W3133951171 cites W3023555100 @default.
• W3133951171 cites W3025294945 @default.
• W3133951171 cites W3044051634 @default.
• W3133951171 cites W3088879600 @default.
• W3133951171 cites W42719055 @default.
• W3133951171 doi "https://doi.org/10.1016/j.jphs.2021.03.001" @default.
• W3133951171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33858655" @default.
• W3133951171 hasPublicationYear "2021" @default.
• W3133951171 type Work @default.
• W3133951171 sameAs 3133951171 @default.
• W3133951171 citedByCount "11" @default.
• W3133951171 countsByYear W31339511712021 @default.
• W3133951171 countsByYear W31339511712022 @default.
• W3133951171 countsByYear W31339511712023 @default.
• W3133951171 crossrefType "journal-article" @default.
• W3133951171 hasAuthorship W3133951171A5026511895 @default.
• W3133951171 hasAuthorship W3133951171A5030587024 @default.
• W3133951171 hasAuthorship W3133951171A5031334106 @default.
• W3133951171 hasAuthorship W3133951171A5035020827 @default.
• W3133951171 hasAuthorship W3133951171A5037553054 @default.
• W3133951171 hasAuthorship W3133951171A5054907762 @default.
• W3133951171 hasAuthorship W3133951171A5062528334 @default.
• W3133951171 hasAuthorship W3133951171A5071654647 @default.
• W3133951171 hasAuthorship W3133951171A5075514275 @default.
• W3133951171 hasAuthorship W3133951171A5088676109 @default.
• W3133951171 hasBestOaLocation W31339511711 @default.
• W3133951171 hasConcept C121608353 @default.
• W3133951171 hasConcept C126322002 @default.
• W3133951171 hasConcept C134018914 @default.
• W3133951171 hasConcept C143998085 @default.
• W3133951171 hasConcept C2776694085 @default.
• W3133951171 hasConcept C2777164284 @default.
• W3133951171 hasConcept C2777292972 @default.
• W3133951171 hasConcept C2779289229 @default.
• W3133951171 hasConcept C2779901536 @default.
• W3133951171 hasConcept C46699223 @default.
• W3133951171 hasConcept C530470458 @default.
• W3133951171 hasConcept C555293320 @default.
• W3133951171 hasConcept C71315377 @default.
• W3133951171 hasConcept C71924100 @default.
• W3133951171 hasConceptScore W3133951171C121608353 @default.
• W3133951171 hasConceptScore W3133951171C126322002 @default.
• W3133951171 hasConceptScore W3133951171C134018914 @default.
• W3133951171 hasConceptScore W3133951171C143998085 @default.
• W3133951171 hasConceptScore W3133951171C2776694085 @default.
• W3133951171 hasConceptScore W3133951171C2777164284 @default.
• W3133951171 hasConceptScore W3133951171C2777292972 @default.
• W3133951171 hasConceptScore W3133951171C2779289229 @default.
• W3133951171 hasConceptScore W3133951171C2779901536 @default.
• W3133951171 hasConceptScore W3133951171C46699223 @default.
• W3133951171 hasConceptScore W3133951171C530470458 @default.

• next