Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133958426> ?p ?o ?g. }
- W3133958426 endingPage "757" @default.
- W3133958426 startingPage "719" @default.
- W3133958426 abstract "The enigmatic eosinophil has emerged as an exciting component of the immune system, involved in a plethora of homeostatic and inflammatory responses. Substantial progress has been achieved through experimental systems manipulating eosinophils in vivo, initially in mice and more recently in humans. Researchers using eosinophil knockout mice have identified a contributory role for eosinophils in basal and inflammatory processes and protective immunity. Primarily fueled by the purported proinflammatory role of eosinophils in eosinophil-associated diseases, a series of anti-eosinophil therapeutics have emerged as a new class of drugs. These agents, which dramatically deplete eosinophils, provide a valuable opportunity to characterize the consequences of eosinophil knockout humans. Herein, we comparatively describe mouse and human eosinophil knockouts. We put forth the view that human eosinophils negatively contribute to a variety of diseases and, unlike mouse eosinophils, do not yet have an identified role in physiological health; thus, clarifying all roles of eosinophils remains an ongoing pursuit." @default.
- W3133958426 created "2021-03-15" @default.
- W3133958426 creator A5003283589 @default.
- W3133958426 creator A5033250803 @default.
- W3133958426 creator A5046236328 @default.
- W3133958426 creator A5056199997 @default.
- W3133958426 creator A5056639915 @default.
- W3133958426 creator A5072613674 @default.
- W3133958426 creator A5073147866 @default.
- W3133958426 creator A5078033835 @default.
- W3133958426 creator A5078489750 @default.
- W3133958426 date "2021-04-26" @default.
- W3133958426 modified "2023-10-10" @default.
- W3133958426 title "Eosinophil Knockout Humans: Uncovering the Role of Eosinophils Through Eosinophil-Directed Biological Therapies" @default.
- W3133958426 cites W105738010 @default.
- W3133958426 cites W1485388451 @default.
- W3133958426 cites W1515144800 @default.
- W3133958426 cites W1529615153 @default.
- W3133958426 cites W1557765112 @default.
- W3133958426 cites W1574141134 @default.
- W3133958426 cites W1597914355 @default.
- W3133958426 cites W1790588053 @default.
- W3133958426 cites W1916962812 @default.
- W3133958426 cites W1926391481 @default.
- W3133958426 cites W1955652166 @default.
- W3133958426 cites W1964729140 @default.
- W3133958426 cites W1965349495 @default.
- W3133958426 cites W1965786377 @default.
- W3133958426 cites W1965860865 @default.
- W3133958426 cites W1968876836 @default.
- W3133958426 cites W1970354614 @default.
- W3133958426 cites W1970648068 @default.
- W3133958426 cites W1972474621 @default.
- W3133958426 cites W1974262000 @default.
- W3133958426 cites W1979245738 @default.
- W3133958426 cites W1982237578 @default.
- W3133958426 cites W1983203108 @default.
- W3133958426 cites W1983631422 @default.
- W3133958426 cites W1986803622 @default.
- W3133958426 cites W1988264238 @default.
- W3133958426 cites W1988742135 @default.
- W3133958426 cites W1988758075 @default.
- W3133958426 cites W1992648705 @default.
- W3133958426 cites W1993253390 @default.
- W3133958426 cites W1993680854 @default.
- W3133958426 cites W1994585625 @default.
- W3133958426 cites W1996244208 @default.
- W3133958426 cites W1996970629 @default.
- W3133958426 cites W1999353686 @default.
- W3133958426 cites W1999705022 @default.
- W3133958426 cites W2000650705 @default.
- W3133958426 cites W2002980147 @default.
- W3133958426 cites W2005186531 @default.
- W3133958426 cites W2006153464 @default.
- W3133958426 cites W2007365836 @default.
- W3133958426 cites W2009357776 @default.
- W3133958426 cites W2010741608 @default.
- W3133958426 cites W2012952884 @default.
- W3133958426 cites W2013216778 @default.
- W3133958426 cites W2013221728 @default.
- W3133958426 cites W2016952830 @default.
- W3133958426 cites W2018473648 @default.
- W3133958426 cites W2020244184 @default.
- W3133958426 cites W2020703181 @default.
- W3133958426 cites W2025830579 @default.
- W3133958426 cites W2027388989 @default.
- W3133958426 cites W2030633414 @default.
- W3133958426 cites W2031035248 @default.
- W3133958426 cites W2031517139 @default.
- W3133958426 cites W2032634575 @default.
- W3133958426 cites W2033559734 @default.
- W3133958426 cites W2033946555 @default.
- W3133958426 cites W2037616254 @default.
- W3133958426 cites W2037801848 @default.
- W3133958426 cites W2039930386 @default.
- W3133958426 cites W2040487176 @default.
- W3133958426 cites W2043027238 @default.
- W3133958426 cites W2044303311 @default.
- W3133958426 cites W2049426078 @default.
- W3133958426 cites W2050068982 @default.
- W3133958426 cites W2050753573 @default.
- W3133958426 cites W2054526270 @default.
- W3133958426 cites W2056975585 @default.
- W3133958426 cites W2057085451 @default.
- W3133958426 cites W2061276567 @default.
- W3133958426 cites W2062918919 @default.
- W3133958426 cites W2063178809 @default.
- W3133958426 cites W2063221575 @default.
- W3133958426 cites W2063359234 @default.
- W3133958426 cites W2064443141 @default.
- W3133958426 cites W2064899968 @default.
- W3133958426 cites W2065797637 @default.
- W3133958426 cites W2071282917 @default.
- W3133958426 cites W2071587163 @default.
- W3133958426 cites W2072518056 @default.
- W3133958426 cites W2073180138 @default.
- W3133958426 cites W2073959308 @default.
- W3133958426 cites W2077464872 @default.