FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3133980185> ?p ?o ?g. }

• W3133980185 abstract "Background: Allylnitrile is a compound found in cruciferous vegetables and has the same lethality and toxic effects as the other nitriles. In 2013, a viable allylnitrile ototoxicity mouse model was established. The toxicity of allylnitrile was limited through inhibition of CYP2E1 with trans-1,2-dichloroethylene (TDCE). The allylnitrile intoxication model has been extensively tested in the 129S1 mouse strain for vestibular function, which showed significant HC loss in the vestibular organ accompanied by severe behavioral abnormalities. However, the effect of allylnitrile on auditory function remains to be evaluated. Commonly used anesthetics to conduct hearing measurements are isoflurane and ketamine/xylazine anesthesia but the effect of these anesthetics on hearing assessment is still unknown. In this study we will evaluate the otovestibular effects of oral allylnitrile administration in mice. In addition, we will compare the influence of isoflurane and ketamine/xylazine anesthesia on hearing thresholds. Methods and Materials: Fourteen Coch+/- CBACa mice were randomly allocated into an allylnitrile (n = 8) and a control group (n = 6). Baseline measurements were done with isoflurane and 1 week later under ketamine/xylazine anesthesia. After baseline audiovestibular measurements, mice were co-administered with a single dose of allylnitrile and, to reduce systemic toxicity, three intraperitoneal injections of TDCE were given. Hearing loss was evaluated by recordings of auditory brainstem responses (ABR) and distortion product otoacoustic emissions (DPOAE). Specific behavioral test batteries for vestibular function were used to assess alterations in vestibular function. Results: Hearing thresholds were significantly elevated when using isoflurane anesthesia compared to ketamine/xylazine anesthesia for all frequencies of the ABR and the mid-to-high frequencies in DPOAE. Allylnitrile-treated mice lacked detectable ABR thresholds at each frequency tested, while DPOAE thresholds were significantly elevated in the low-frequency region of the cochlea and completely lacking in the mid-to high frequency region. Vestibular function was not affected by allylnitrile administration. Conclusion: Isoflurane anesthesia has a negative confounding effect on the measurement of hearing thresholds in mice. A single oral dose of allylnitrile induced hearing loss but did not significantly alter vestibular function in mice. This is the first study to show that administration of allylnitrile can cause a complete loss of hearing function in mice." @default.
• W3133980185 created "2021-03-15" @default.
• W3133980185 creator A5021024474 @default.
• W3133980185 creator A5026722299 @default.
• W3133980185 creator A5027033208 @default.
• W3133980185 creator A5035062743 @default.
• W3133980185 creator A5042452497 @default.
• W3133980185 creator A5049558588 @default.
• W3133980185 creator A5057945874 @default.
• W3133980185 creator A5088180974 @default.
• W3133980185 creator A5090788428 @default.
• W3133980185 date "2021-02-25" @default.
• W3133980185 modified "2023-10-16" @default.
• W3133980185 title "Effect of Oral Allylnitrile Administration on Cochlear Functioning in Mice Following Comparison of Different Anesthetics for Hearing Assessment" @default.
• W3133980185 cites W1966477239 @default.
• W3133980185 cites W1969994570 @default.
• W3133980185 cites W1974193656 @default.
• W3133980185 cites W1975876105 @default.
• W3133980185 cites W1978989391 @default.
• W3133980185 cites W1979683450 @default.
• W3133980185 cites W1981462008 @default.
• W3133980185 cites W1984878610 @default.
• W3133980185 cites W1985835614 @default.
• W3133980185 cites W1986599364 @default.
• W3133980185 cites W1987120335 @default.
• W3133980185 cites W1988501412 @default.
• W3133980185 cites W1996442906 @default.
• W3133980185 cites W1998363879 @default.
• W3133980185 cites W2001783543 @default.
• W3133980185 cites W2006765814 @default.
• W3133980185 cites W2012717802 @default.
• W3133980185 cites W2027640539 @default.
• W3133980185 cites W2028833397 @default.
• W3133980185 cites W2037219904 @default.
• W3133980185 cites W2039264573 @default.
• W3133980185 cites W2042871452 @default.
• W3133980185 cites W2047218400 @default.
• W3133980185 cites W2049460161 @default.
• W3133980185 cites W2053556274 @default.
• W3133980185 cites W2054512542 @default.
• W3133980185 cites W2061617105 @default.
• W3133980185 cites W2064252714 @default.
• W3133980185 cites W2065097602 @default.
• W3133980185 cites W2074540388 @default.
• W3133980185 cites W2080107601 @default.
• W3133980185 cites W2080713395 @default.
• W3133980185 cites W2082313150 @default.
• W3133980185 cites W2082368133 @default.
• W3133980185 cites W2087608823 @default.
• W3133980185 cites W2087618995 @default.
• W3133980185 cites W2097612215 @default.
• W3133980185 cites W2130002964 @default.
• W3133980185 cites W2136212718 @default.
• W3133980185 cites W2137604698 @default.
• W3133980185 cites W2143307056 @default.
• W3133980185 cites W2145417887 @default.
• W3133980185 cites W2183128938 @default.
• W3133980185 cites W2199236088 @default.
• W3133980185 cites W2319824160 @default.
• W3133980185 cites W2320927083 @default.
• W3133980185 cites W2520923349 @default.
• W3133980185 cites W2535589380 @default.
• W3133980185 cites W2546800380 @default.
• W3133980185 cites W2564131244 @default.
• W3133980185 cites W2582348217 @default.
• W3133980185 cites W2790054710 @default.
• W3133980185 cites W2795686827 @default.
• W3133980185 cites W2915573048 @default.
• W3133980185 cites W2946447360 @default.
• W3133980185 cites W4211253709 @default.
• W3133980185 cites W4248395310 @default.
• W3133980185 cites W91173676 @default.
• W3133980185 doi "https://doi.org/10.3389/ftox.2021.641569" @default.
• W3133980185 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35295154" @default.
• W3133980185 hasPublicationYear "2021" @default.
• W3133980185 type Work @default.
• W3133980185 sameAs 3133980185 @default.
• W3133980185 citedByCount "0" @default.
• W3133980185 crossrefType "journal-article" @default.
• W3133980185 hasAuthorship W3133980185A5021024474 @default.
• W3133980185 hasAuthorship W3133980185A5026722299 @default.
• W3133980185 hasAuthorship W3133980185A5027033208 @default.
• W3133980185 hasAuthorship W3133980185A5035062743 @default.
• W3133980185 hasAuthorship W3133980185A5042452497 @default.
• W3133980185 hasAuthorship W3133980185A5049558588 @default.
• W3133980185 hasAuthorship W3133980185A5057945874 @default.
• W3133980185 hasAuthorship W3133980185A5088180974 @default.
• W3133980185 hasAuthorship W3133980185A5090788428 @default.
• W3133980185 hasBestOaLocation W31339801851 @default.
• W3133980185 hasConcept C126322002 @default.
• W3133980185 hasConcept C190041318 @default.
• W3133980185 hasConcept C2776359302 @default.
• W3133980185 hasConcept C2776694085 @default.
• W3133980185 hasConcept C2778239845 @default.
• W3133980185 hasConcept C2778534666 @default.
• W3133980185 hasConcept C2779591255 @default.
• W3133980185 hasConcept C2780493683 @default.
• W3133980185 hasConcept C2780795376 @default.
• W3133980185 hasConcept C2780941679 @default.
• W3133980185 hasConcept C29730261 @default.

• next