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- W3134043562 abstract "• Three main maytansinoids from Trewia nudiflora were isolated and identified. • Maytansinoids exhibited strong cytotoxicities and were used as analytes. • A QuEChERS method was established for extraction of the analytes. • The QuEChERS–HPLC method is applicable to determination of maytansinoids in T. nudiflora . Three maytansinoids with strong cytotoxicities, dehydrotrewiasine, maytanbutine, and trewiasine, were isolated and identified from Trewia nudiflora , and maytanbutine was obtained from this plant for the first time. A quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction combined with high-performance liquid chromatography (HPLC) was established to determine the three maytansinoids in T. nudiflora . The effects of major factors on the extraction efficiency of the QuEChERS method were evaluated and the optimal conditions using acetonitrile-ethyl acetate (1:1, v/v) as the extraction solvent and PestiCarb as the clean-up sorbents were established. Compared with Soxhlet extraction (SE) and ultrasonic-assisted extraction (UAE), the QuEChERS method was easy-to-operate and afforded a cleaner extract. A phenomenex HyperClone BDS C 18 column was used for HPLC analysis. Methanol-acetonitrile-water was chosen as mobile phase for gradient elution. Method validation showed that all analytes showed good linearity ( r > 0.999) over the investigated ranges and satisfactory recoveries ranging from 95.0% to 105.0%. The developed QuEChERS–HPLC method was simple, efficient, and applicable to the determination of maytansinoids in T. nudiflora ." @default.
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- W3134043562 date "2021-05-01" @default.
- W3134043562 modified "2023-10-17" @default.
- W3134043562 title "Determination of maytansinoids in Trewia nudiflora using QuEChERS extraction combined with HPLC" @default.
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- W3134043562 doi "https://doi.org/10.1016/j.jpba.2021.113993" @default.
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