FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134051383> ?p ?o ?g. }

• W3134051383 abstract "Abstract Dosage compensation is a mechanism that equalizes sex chromosome gene expression between the sexes. In Drosophila , individuals with two X chromosomes (XX) become female, whereas males have one X chromosome (XY). In males, dosage compensation of the X chromosome in the soma is achieved by five proteins and two non-coding RNAs, which assemble into the male-specific lethal (MSL) complex to upregulate X-linked genes twofold. By contrast, it remains unclear whether dosage compensation occurs in the germline. To address this issue, we performed transcriptome analysis of male and female primordial germ cells (PGCs). We found that the expression levels of X-linked genes were approximately twofold higher in female PGCs than in male PGCs. Acetylation of lysine residue 16 on histone H4 (H4K16ac), which is catalyzed by the MSL complex, was undetectable in these cells. In male PGCs, hyperactivation of X-linked genes and H4K16ac were induced by overexpression of the essential components of the MSL complex, which were expressed at very low levels in PGCs. Together, these findings indicate that failure of MSL complex formation results in the absence of X-chromosome dosage compensation in male PGCs." @default.
• W3134051383 created "2021-03-15" @default.
• W3134051383 creator A5003451456 @default.
• W3134051383 creator A5053848574 @default.
• W3134051383 creator A5059739109 @default.
• W3134051383 creator A5080910218 @default.
• W3134051383 creator A5085897151 @default.
• W3134051383 date "2021-03-01" @default.
• W3134051383 modified "2023-10-16" @default.
• W3134051383 title "Absence of X-chromosome dosage compensation in the primordial germ cells of Drosophila embryos" @default.
• W3134051383 cites W1516735761 @default.
• W3134051383 cites W1972844374 @default.
• W3134051383 cites W1984509766 @default.
• W3134051383 cites W1990022233 @default.
• W3134051383 cites W1991136421 @default.
• W3134051383 cites W1992429247 @default.
• W3134051383 cites W1999258547 @default.
• W3134051383 cites W2006922495 @default.
• W3134051383 cites W2015150527 @default.
• W3134051383 cites W2023994991 @default.
• W3134051383 cites W2029086784 @default.
• W3134051383 cites W2029098371 @default.
• W3134051383 cites W2032165553 @default.
• W3134051383 cites W2038652674 @default.
• W3134051383 cites W2038661934 @default.
• W3134051383 cites W2044800513 @default.
• W3134051383 cites W2046620588 @default.
• W3134051383 cites W2048432197 @default.
• W3134051383 cites W2052112605 @default.
• W3134051383 cites W2059843465 @default.
• W3134051383 cites W2063950568 @default.
• W3134051383 cites W2065050462 @default.
• W3134051383 cites W2072108339 @default.
• W3134051383 cites W2076566576 @default.
• W3134051383 cites W2081049732 @default.
• W3134051383 cites W2092702114 @default.
• W3134051383 cites W2093846964 @default.
• W3134051383 cites W2096060868 @default.
• W3134051383 cites W2106835425 @default.
• W3134051383 cites W2114104545 @default.
• W3134051383 cites W2131271579 @default.
• W3134051383 cites W2136417358 @default.
• W3134051383 cites W2141511112 @default.
• W3134051383 cites W2148019518 @default.
• W3134051383 cites W2155150900 @default.
• W3134051383 cites W2155779595 @default.
• W3134051383 cites W2157302098 @default.
• W3134051383 cites W2164131112 @default.
• W3134051383 cites W2167496283 @default.
• W3134051383 cites W2171624251 @default.
• W3134051383 cites W2323326409 @default.
• W3134051383 cites W2466317112 @default.
• W3134051383 cites W2530474651 @default.
• W3134051383 cites W2571369116 @default.
• W3134051383 cites W2768078685 @default.
• W3134051383 cites W2802006048 @default.
• W3134051383 cites W2964047789 @default.
• W3134051383 cites W3008137528 @default.
• W3134051383 cites W3009525101 @default.
• W3134051383 cites W3018591629 @default.
• W3134051383 doi "https://doi.org/10.1038/s41598-021-84402-7" @default.
• W3134051383 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7921590" @default.
• W3134051383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33649478" @default.
• W3134051383 hasPublicationYear "2021" @default.
• W3134051383 type Work @default.
• W3134051383 sameAs 3134051383 @default.
• W3134051383 citedByCount "3" @default.
• W3134051383 countsByYear W31340513832021 @default.
• W3134051383 countsByYear W31340513832022 @default.
• W3134051383 countsByYear W31340513832023 @default.
• W3134051383 crossrefType "journal-article" @default.
• W3134051383 hasAuthorship W3134051383A5003451456 @default.
• W3134051383 hasAuthorship W3134051383A5053848574 @default.
• W3134051383 hasAuthorship W3134051383A5059739109 @default.
• W3134051383 hasAuthorship W3134051383A5080910218 @default.
• W3134051383 hasAuthorship W3134051383A5085897151 @default.
• W3134051383 hasBestOaLocation W31340513831 @default.
• W3134051383 hasConcept C104317684 @default.
• W3134051383 hasConcept C109825262 @default.
• W3134051383 hasConcept C150194340 @default.
• W3134051383 hasConcept C162317418 @default.
• W3134051383 hasConcept C196843134 @default.
• W3134051383 hasConcept C2590687 @default.
• W3134051383 hasConcept C2779085176 @default.
• W3134051383 hasConcept C2779122487 @default.
• W3134051383 hasConcept C2780246931 @default.
• W3134051383 hasConcept C30481170 @default.
• W3134051383 hasConcept C35158069 @default.
• W3134051383 hasConcept C4323932 @default.
• W3134051383 hasConcept C54355233 @default.
• W3134051383 hasConcept C55548728 @default.
• W3134051383 hasConcept C64927066 @default.
• W3134051383 hasConcept C86803240 @default.
• W3134051383 hasConcept C92509807 @default.
• W3134051383 hasConcept C95444343 @default.
• W3134051383 hasConceptScore W3134051383C104317684 @default.
• W3134051383 hasConceptScore W3134051383C109825262 @default.
• W3134051383 hasConceptScore W3134051383C150194340 @default.
• W3134051383 hasConceptScore W3134051383C162317418 @default.
• W3134051383 hasConceptScore W3134051383C196843134 @default.

• next