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• W3134082013 abstract "Abstract Background and Objective Diabetes accelerates inflammaging in various tissue with an increase in senescent cell burden and senescence‐associated secretory phenotype (SASP) secretion, which is a significant cause of tissue dysfunction and contributes to the diabetic complications. Recently, inflammasomes are thought to contribute to inflammaging. Here, utilizing diabetic models in vivo and in vitro, we investigated the potential association between hyperglycemia‐induced inflammaging and gingival tissue dysfunction and the mechanism underlying inflammasome‐associated inflammaging. Materials and Methods Gingival epithelium and serum were collected from control and diabetic patients and mice. The expression of p16, p21, and inflammasomes in the gingival epithelium, SASP factors in serum, and the molecular factors associated with gingival epithelial barrier function were assessed. Human oral keratinocyte (HOK) was stimulated with normal and high glucose, and pre‐treated with Z‐YVAD‐FMK (Caspase‐1 inhibitor) prior to evaluating cellular senescence, SASP secretion, and inflammasome activation. Results In vivo, hyperglycemia significantly elevated the local burden of senescent cells in the gingival epithelium and SASP factors in the serum and simultaneously reduced the expression levels of Claudin‐1, E‐cadherin, and Connexin 43 in the gingival epithelium. Interestingly, the inflammasomes were activated in the gingival epithelium. In vitro, high glucose‐induced the inflammaging in HOK, and blocking inflammasome activation through inhibiting Caspase‐1 and glucose‐induced inflammaging. Conclusions Hyperglycemia accelerated inflammaging in the gingival epithelium through inflammasomes activation, which is potentially affiliated with a decline in the gingival epithelial barrier function in diabetes. Inflammasomes‐related inflammaging may be the crucial mechanism underlying diabetic periodontitis and represents significant opportunities for advancing prevention and treatment options." @default.
• W3134082013 created "2021-03-15" @default.
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• W3134082013 date "2021-03-02" @default.
• W3134082013 modified "2023-10-16" @default.
• W3134082013 title "Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation" @default.
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• W3134082013 doi "https://doi.org/10.1111/jre.12863" @default.
• W3134082013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33650689" @default.
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