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- W3134107905 abstract "Cardiovascular disease is the leading cause of mortality and morbidity around the globe, creating a substantial socio-economic burden as a result. Myocardial infarction is a significant contributor to the detrimental impact of cardiovascular disease. The death of cardiomyocytes following myocardial infarction causes an immune response which leads to further destruction of tissue, and subsequently, results in the formation of non-contractile scar tissue. Macrophages have been recognized as important regulators and participants of inflammation and fibrosis following myocardial infarction. Macrophages are generally classified into two distinct groups, namely, classically activated, or M1 macrophages, and alternatively activated, or M2 macrophages. The phenotypic profile of cardiac macrophages, however, is much more diverse and should not be reduced to these two subsets. In this review, we describe the phenotypes and functions of macrophages which are present in the healthy, as well as the infarcted heart, and analyze them with respect to M1 and M2 polarization states. Furthermore, we discuss therapeutic strategies which utilize macrophage polarization towards an anti-inflammatory or reparative phenotype for the treatment of myocardial infarction." @default.
- W3134107905 created "2021-03-15" @default.
- W3134107905 creator A5005825338 @default.
- W3134107905 creator A5010780569 @default.
- W3134107905 creator A5030013208 @default.
- W3134107905 creator A5030156613 @default.
- W3134107905 creator A5075686575 @default.
- W3134107905 date "2021-03-08" @default.
- W3134107905 modified "2023-10-10" @default.
- W3134107905 title "Macrophage Polarization in Cardiac Tissue Repair Following Myocardial Infarction" @default.
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