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- W3134123325 abstract "Introduction: Lupus nephritis (LN) is a serious complication of systemic lupus erythematosus with disparity of prevalence and severity in different race, ethnicity and country. Present studyaims to find out different profile of biopsy proven Lupus nephritis patients.Method: This is a retrospective review of records of biopsy proven lupus nephritis from May 2012 to April 2017. The demography, ethnicity, clinical and laboratory parameters,International Societyof Nephrology/Renal Pathology Society Classification with activity and chronicity index in kidney biopsy reports were recorded in a pro-forma.Result: Sample size was 106 with predominant young females (93%). The mean age was 27.9 + 9.6 years and 73% in age of 20-39 years.Janajati (51%) and tharu (25%) were the major ethnicityand caste affected respectively. Hematological involvement (79%) and arthralgia (67%) were the commonest extra-renalmanifestations and serology was positive in 100% with ANA (95%) and anti ds Deoxyribonucleic acid (83%) and both positive in 78%. Both American College of Rheumatology and the SystemicLupus International Collaborating Clinics criteria for diagnosis of SLE revealed > 4 criteria present in 96% patients.Renal manifestations were proteinuria (100%), edema (77%), microscopic hematuria (54%) hypertension (47%), renal impairment (42%) and nephrotic range proteinuria (25%). Class IVLN was diagnosed in 66% with significantly higher activity (10.4+3.3, p=0.000) and chronicity (2.5+1.5, p=0.036) index, lower hemoglobin (9.6+1.9 g/dl, p=0.039) and higher prevalence injanajati (75%, p=0.04) and tharu (81%, p=0.04) community compared to other class. Conclusion: LN affected predominantly young females of janajati and tharu community with highly active class IV LN at presentation among Nepalese Patients.Keywords: Ethnicity, Histopathology, Lupus nephritis, Renal biopsy, Systemic lupus erythematosus" @default.
- W3134123325 created "2021-03-15" @default.
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- W3134123325 date "2020-01-27" @default.
- W3134123325 modified "2023-09-27" @default.
- W3134123325 title "Profile of Biopsy Proven Lupus Nephritis at a Referral Hospital in Nepal" @default.
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