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• W3134132730 abstract "Background and purpose: 68Ga DOTATATE PET/CT protocols are similar to 18F FDG protocols despite differences in physical properties, biodistribution, and tumor uptake. The purpose of this study is to evaluate the impact of scan time (counts), and target activity on signal-to-noise ratio (SNR) in various sized targets, or lesions. To evaluate this, phantom experiments and analysis of clinical 68Ga DOTATATE PET/CT studies were performed. Materials and methods: 68Ga was first compared to 18F in phantom studies to evaluate recovery coefficients and SNR. 68Ga phantom studies were also acquired in list mode, and at varying target activities to evaluate the effects of acquisition time and high target concentrations on SNR in clinically relevant small (8 mm) and larger targets (≥ 12 mm). Clinical studies (n = 50) were analyzed to determine if phantom target concentrations and SNR are present in clinical 68Ga DOTATATE studies at similarly very high tumor activity concentrations (n = 159). Results: In phantoms, recovery coefficient and SUVmax for 68Ga were ~87% of 18F. SNR for 68Ga was ~65% of 18F. For the 68Ga small target (8 mm) at standard T/B = 2.4, increasing scan time from 5 to 15 minutes increased SNR from < 1 to 1.6, and did not result in target identification. Increasing T/B from 2.4 to 10.9, however, dramatically increased SNR from < 1 to 22.3. Increased T/B resulted in clear visibility of the 8 mm target, even for 1-minute scans. In patients, high hepatic tumor SUVmax (27.3±29.6), resulted in high SNR (12.5±9.8). For extrahepatic tumors, high SUVmax (41.6±42.8), resulted in high SNR (43.8±49.9). Conclusion: Very high target or T/B, even in small targets, can offset the physical limitations of 68Ga. High target uptake and high T/B are primary factors influencing small lesion detectability." @default.
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• W3134132730 date "2021-02-15" @default.
• W3134132730 modified "2023-09-25" @default.
• W3134132730 title "Physical characteristics of 68 Ga DOTATATE PET/CT affecting small lesion detectability" @default.
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