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- W3134197434 abstract "Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked desmoplasia and drug resistance due, in part, to poor drug delivery to extravascular tumor tissue. Here, we report that carcinoma-associated fibroblasts (CAFs) induce β5 integrin expression in tumor cells in a TGF-β dependent manner, making them an efficient drug delivery target for the tumor-penetrating peptide iRGD. The capacity of iRGD to deliver conjugated and co-injected payloads is markedly suppressed when β5 integrins are knocked out in the tumor cells. Of note, β5 integrin knock-out in tumor cells leads to reduced disease burden and prolonged survival of the mice, demonstrating its contribution to PDAC progression. iRGD significantly potentiates co-injected chemotherapy in KPC mice with high β5 integrin expression and may be a powerful strategy to target an aggressive PDAC subpopulation." @default.
- W3134197434 created "2021-03-15" @default.
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- W3134197434 date "2021-03-09" @default.
- W3134197434 modified "2023-10-10" @default.
- W3134197434 title "Tumor-penetrating therapy for β5 integrin-rich pancreas cancer" @default.
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- W3134197434 doi "https://doi.org/10.1038/s41467-021-21858-1" @default.
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