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- W3134202315 endingPage "102355" @default.
- W3134202315 startingPage "102355" @default.
- W3134202315 abstract "Clostridioides difficile is an emerging One Health pathogen and a common etiologic agent of diarrhea, both in healthcare settings and the community. This bacterial species is highly diverse, and its global population has been classified in eight clades by multilocus sequence typing (MLST). The C. difficile MLST Clade 2 includes the NAP1/RT027/ST01 strain, which is highly recognized due to its epidemicity and association with severe disease presentation and mortality. By contrast, the remaining 83 sequence types (STs) that compose this clade have received much less attention. In response to this shortcoming, we reviewed articles published in English between 1999 and 2020 and collected information for 27 Clade 2 STs, with an emphasis on STs 01, 67, 41 and 188/231/365. Our analysis provides evidence of large phenotypic differences that preclude support of the rather widespread notion that ST01 and Clade 2 strains are “hypervirulent”. Moreover, it revealed a profound lack of (meta)data for nearly 70% of the Clade 2 STs that have been identified in surveillance efforts. Targeted studies aiming to relate wet-lab and bioinformatics results to patient and clinical parameters should be performed to gain a more in-depth insight into the biology of this intriguing group of C. difficile isolates." @default.
- W3134202315 created "2021-03-15" @default.
- W3134202315 creator A5011811419 @default.
- W3134202315 creator A5020274273 @default.
- W3134202315 date "2021-06-01" @default.
- W3134202315 modified "2023-10-18" @default.
- W3134202315 title "Microbiological features, epidemiology, and clinical presentation of Clostridioides difficile strains from MLST Clade 2: A narrative review" @default.
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- W3134202315 doi "https://doi.org/10.1016/j.anaerobe.2021.102355" @default.
- W3134202315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33711422" @default.
- W3134202315 hasPublicationYear "2021" @default.
- W3134202315 type Work @default.