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- W3134211532 abstract "This scoping review examines the evidence for n-3 long-chain polyunsaturated fatty acid [LCPUFA, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] supplementation in clinical cancer therapy. A comprehensive literature search was performed to identify relevant clinical intervention studies conducted through August 2020. Fifty-seven unique cancer trials, assessing EPA and/or DHA supplementation pre- or post-treatment, concomitant with neoadjuvant chemotherapy, radiation or surgery, or in palliative therapy were included. Breast, head and neck, gastrointestinal, gastric, colorectal/rectal, esophageal, leukemia/lymphoma, lung, multiple myeloma and pancreatic cancers were investigated. Across the spectrum of cancers, the evidence suggests that supplementation increased or maintained body weight, increased progression-free and overall survival, improved overall quality of life, resulted in beneficial change in immune parameters and decreased serious adverse events. Taken together, the data support that EPA and/or DHA could be used to improve outcomes important to the patient and disease process. However, before incorporation into treatment can occur, there is a need for randomized clinical trials to determine the dose and type of n-3 LCPUFA intervention required, and expansion of outcomes assessed and improved reporting of outcomes." @default.
- W3134211532 created "2021-03-15" @default.
- W3134211532 creator A5024069846 @default.
- W3134211532 creator A5069867977 @default.
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- W3134211532 date "2021-03-10" @default.
- W3134211532 modified "2023-10-16" @default.
- W3134211532 title "N-3 Long-Chain Polyunsaturated Fatty Acids, Eicosapentaenoic and Docosahexaenoic Acid, and the Role of Supplementation during Cancer Treatment: A Scoping Review of Current Clinical Evidence" @default.
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- W3134211532 doi "https://doi.org/10.3390/cancers13061206" @default.
- W3134211532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8000768" @default.
- W3134211532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33801979" @default.
- W3134211532 hasPublicationYear "2021" @default.
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