Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134220384> ?p ?o ?g. }
- W3134220384 endingPage "377" @default.
- W3134220384 startingPage "377" @default.
- W3134220384 abstract "RAS proteins are mutated in approximately 20% of all cancers and are generally associated with poor clinical outcomes. RAS proteins are localized to the plasma membrane and function as molecular switches, turned on by partners that receive extracellular mitogenic signals. In the on-state, they activate intracellular signal transduction cascades. Membrane-bound RAS molecules segregate into multimers, known as nanoclusters. These nanoclusters, held together through weak protein–protein and protein–lipid associations, are highly dynamic and respond to cellular input signals and fluctuations in the local lipid environment. Disruption of RAS nanoclusters results in downregulation of RAS-mediated mitogenic signaling. In this review, we discuss the propensity of RAS proteins to display clustering behavior and the interfaces that are associated with these assemblies. Strategies to therapeutically disrupt nanocluster formation or the stabilization of signaling incompetent RAS complexes are discussed." @default.
- W3134220384 created "2021-03-15" @default.
- W3134220384 creator A5032271287 @default.
- W3134220384 creator A5032677403 @default.
- W3134220384 creator A5041554247 @default.
- W3134220384 creator A5061593035 @default.
- W3134220384 creator A5070024846 @default.
- W3134220384 creator A5084185294 @default.
- W3134220384 date "2021-03-03" @default.
- W3134220384 modified "2023-10-11" @default.
- W3134220384 title "RAS Nanoclusters: Dynamic Signaling Platforms Amenable to Therapeutic Intervention" @default.
- W3134220384 cites W1492513673 @default.
- W3134220384 cites W1535997186 @default.
- W3134220384 cites W1556741602 @default.
- W3134220384 cites W1581417572 @default.
- W3134220384 cites W1839280013 @default.
- W3134220384 cites W1852817901 @default.
- W3134220384 cites W1914204293 @default.
- W3134220384 cites W1968075591 @default.
- W3134220384 cites W1968877074 @default.
- W3134220384 cites W1970161309 @default.
- W3134220384 cites W1970856032 @default.
- W3134220384 cites W1972738796 @default.
- W3134220384 cites W1980926711 @default.
- W3134220384 cites W1982586481 @default.
- W3134220384 cites W1987195331 @default.
- W3134220384 cites W1996277017 @default.
- W3134220384 cites W1996425695 @default.
- W3134220384 cites W2002036996 @default.
- W3134220384 cites W2003625629 @default.
- W3134220384 cites W2005601312 @default.
- W3134220384 cites W2009956378 @default.
- W3134220384 cites W2012378896 @default.
- W3134220384 cites W2017960640 @default.
- W3134220384 cites W2026150993 @default.
- W3134220384 cites W2034063805 @default.
- W3134220384 cites W2035363409 @default.
- W3134220384 cites W2037870039 @default.
- W3134220384 cites W2038027636 @default.
- W3134220384 cites W2041755933 @default.
- W3134220384 cites W2043450412 @default.
- W3134220384 cites W2058511768 @default.
- W3134220384 cites W2065085147 @default.
- W3134220384 cites W2066784934 @default.
- W3134220384 cites W2074039305 @default.
- W3134220384 cites W2086983907 @default.
- W3134220384 cites W2088064651 @default.
- W3134220384 cites W2091710329 @default.
- W3134220384 cites W2091991032 @default.
- W3134220384 cites W2092613403 @default.
- W3134220384 cites W2117669008 @default.
- W3134220384 cites W2125872855 @default.
- W3134220384 cites W2129653056 @default.
- W3134220384 cites W2133362776 @default.
- W3134220384 cites W2135184154 @default.
- W3134220384 cites W2135371328 @default.
- W3134220384 cites W2146189740 @default.
- W3134220384 cites W2146926552 @default.
- W3134220384 cites W2152444476 @default.
- W3134220384 cites W2163104155 @default.
- W3134220384 cites W2163147836 @default.
- W3134220384 cites W2164565944 @default.
- W3134220384 cites W2167892316 @default.
- W3134220384 cites W2172747448 @default.
- W3134220384 cites W2172885745 @default.
- W3134220384 cites W2257584309 @default.
- W3134220384 cites W2285771040 @default.
- W3134220384 cites W2334993556 @default.
- W3134220384 cites W2363054795 @default.
- W3134220384 cites W2416471421 @default.
- W3134220384 cites W2548573003 @default.
- W3134220384 cites W2571240151 @default.
- W3134220384 cites W2599649240 @default.
- W3134220384 cites W2606059416 @default.
- W3134220384 cites W2735324923 @default.
- W3134220384 cites W2735864034 @default.
- W3134220384 cites W2751274187 @default.
- W3134220384 cites W2773776503 @default.
- W3134220384 cites W2782758955 @default.
- W3134220384 cites W2783525201 @default.
- W3134220384 cites W2783664968 @default.
- W3134220384 cites W2803604922 @default.
- W3134220384 cites W2904125429 @default.
- W3134220384 cites W2907558869 @default.
- W3134220384 cites W2917584371 @default.
- W3134220384 cites W2950908936 @default.
- W3134220384 cites W2963086398 @default.
- W3134220384 cites W2963254306 @default.
- W3134220384 cites W2971311915 @default.
- W3134220384 cites W2983221291 @default.
- W3134220384 cites W2995284457 @default.
- W3134220384 cites W2998848508 @default.
- W3134220384 cites W2999306985 @default.
- W3134220384 cites W3006063697 @default.
- W3134220384 cites W3006302040 @default.
- W3134220384 cites W3013279701 @default.
- W3134220384 cites W3013377779 @default.
- W3134220384 cites W3025364951 @default.