FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134260624> ?p ?o ?g. }

• W3134260624 endingPage "433" @default.
• W3134260624 startingPage "419" @default.
• W3134260624 abstract "This study investigates the effect of PD1 blockade on the therapeutic efficacy of novel doxorubicin-loaded temperature-sensitive liposomes. Herein, we report photothermally-activated, low temperature-sensitive magnetoliposomes (mLTSL) for efficient drug delivery and magnetic resonance imaging (MRI). The mLTSL were prepared by embedding small nitrodopamine palmitate (NDPM)-coated iron oxide nanoparticles (IO NPs) in the lipid bilayer of low temperature-sensitive liposomes (LTSL), using lipid film hydration and extrusion. Doxorubicin (DOX)-loaded mLTSL were characterized using dynamic light scattering, differential scanning calorimetry, electron microscopy, spectrofluorimetry, and atomic absorption spectroscopy. Photothermal experiments using 808 nm laser irradiation were conducted. In vitro photothermal DOX release studies and cytotoxicity was assessed using flow cytometry and resazurin viability assay, respectively. In vivo DOX release and tumor accumulation of mLTSL(DOX) were assessed using fluorescence and MR imaging, respectively. Finally, the therapeutic efficacy of PD1 blockade in combination with photothermally-activated mLTSL(DOX) in CT26-tumor model was evaluated by monitoring tumor growth, cytokine release and immune cell infiltration in the tumor tissue. Interestingly, efficient photothermal heating was obtained by varying the IO NPs content and the laser power, where on-demand burst DOX release was achievable in vitro and in vivo. Moreover, our mLTSL exhibited promising MR imaging properties with high transverse r2 relaxivity (333 mM−1 s−1), resulting in superior MR imaging in vivo. Furthermore, mLTSL(DOX) therapeutic efficacy was potentiated in combination with anti-PD1 mAb, resulting in a significant reduction in CT26 tumor growth via immune cell activation. Our study highlights the potential of combining PD1 blockade with mLTSL(DOX), where the latter could facilitate chemo/photothermal therapy and MRI-guided drug delivery." @default.
• W3134260624 created "2021-03-15" @default.
• W3134260624 creator A5000367231 @default.
• W3134260624 creator A5000543718 @default.
• W3134260624 creator A5001397490 @default.
• W3134260624 creator A5004975546 @default.
• W3134260624 creator A5005916320 @default.
• W3134260624 creator A5018827554 @default.
• W3134260624 creator A5028401323 @default.
• W3134260624 creator A5035571955 @default.
• W3134260624 creator A5041997129 @default.
• W3134260624 creator A5043097979 @default.
• W3134260624 creator A5053771070 @default.
• W3134260624 creator A5056745012 @default.
• W3134260624 creator A5058590028 @default.
• W3134260624 creator A5061849146 @default.
• W3134260624 creator A5063239810 @default.
• W3134260624 creator A5063733658 @default.
• W3134260624 creator A5064417354 @default.
• W3134260624 creator A5070257255 @default.
• W3134260624 creator A5077158987 @default.
• W3134260624 creator A5085509588 @default.
• W3134260624 date "2021-04-01" @default.
• W3134260624 modified "2023-10-03" @default.
• W3134260624 title "PD1 blockade potentiates the therapeutic efficacy of photothermally-activated and MRI-guided low temperature-sensitive magnetoliposomes" @default.
• W3134260624 cites W1571559303 @default.
• W3134260624 cites W1779771004 @default.
• W3134260624 cites W1978521258 @default.
• W3134260624 cites W1988329232 @default.
• W3134260624 cites W1990857187 @default.
• W3134260624 cites W1991980008 @default.
• W3134260624 cites W2016732129 @default.
• W3134260624 cites W2033503179 @default.
• W3134260624 cites W2044840613 @default.
• W3134260624 cites W2045131272 @default.
• W3134260624 cites W2048228776 @default.
• W3134260624 cites W2049169201 @default.
• W3134260624 cites W2056083287 @default.
• W3134260624 cites W2066555244 @default.
• W3134260624 cites W2078694420 @default.
• W3134260624 cites W2092921437 @default.
• W3134260624 cites W2097616315 @default.
• W3134260624 cites W2097748705 @default.
• W3134260624 cites W2111217091 @default.
• W3134260624 cites W2118396147 @default.
• W3134260624 cites W2120426523 @default.
• W3134260624 cites W2140492749 @default.
• W3134260624 cites W2155203762 @default.
• W3134260624 cites W2158249150 @default.
• W3134260624 cites W2291888828 @default.
• W3134260624 cites W2339088174 @default.
• W3134260624 cites W2499172676 @default.
• W3134260624 cites W2533513686 @default.
• W3134260624 cites W2580036324 @default.
• W3134260624 cites W2604496915 @default.
• W3134260624 cites W2619094261 @default.
• W3134260624 cites W2734420337 @default.
• W3134260624 cites W2742803722 @default.
• W3134260624 cites W2756052580 @default.
• W3134260624 cites W2764120652 @default.
• W3134260624 cites W2791998350 @default.
• W3134260624 cites W2802045560 @default.
• W3134260624 cites W2888349638 @default.
• W3134260624 cites W2890152689 @default.
• W3134260624 cites W2892924318 @default.
• W3134260624 cites W2910429314 @default.
• W3134260624 cites W2912677760 @default.
• W3134260624 cites W2945760995 @default.
• W3134260624 cites W2964274846 @default.
• W3134260624 cites W2972201698 @default.
• W3134260624 cites W2981573617 @default.
• W3134260624 cites W2981614789 @default.
• W3134260624 cites W2999252190 @default.
• W3134260624 cites W3005943777 @default.
• W3134260624 cites W3007528056 @default.
• W3134260624 cites W3022941639 @default.
• W3134260624 cites W3085033328 @default.
• W3134260624 doi "https://doi.org/10.1016/j.jconrel.2021.03.002" @default.
• W3134260624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33677010" @default.
• W3134260624 hasPublicationYear "2021" @default.
• W3134260624 type Work @default.
• W3134260624 sameAs 3134260624 @default.
• W3134260624 citedByCount "8" @default.
• W3134260624 countsByYear W31342606242021 @default.
• W3134260624 countsByYear W31342606242022 @default.
• W3134260624 countsByYear W31342606242023 @default.
• W3134260624 crossrefType "journal-article" @default.
• W3134260624 hasAuthorship W3134260624A5000367231 @default.
• W3134260624 hasAuthorship W3134260624A5000543718 @default.
• W3134260624 hasAuthorship W3134260624A5001397490 @default.
• W3134260624 hasAuthorship W3134260624A5004975546 @default.
• W3134260624 hasAuthorship W3134260624A5005916320 @default.
• W3134260624 hasAuthorship W3134260624A5018827554 @default.
• W3134260624 hasAuthorship W3134260624A5028401323 @default.
• W3134260624 hasAuthorship W3134260624A5035571955 @default.
• W3134260624 hasAuthorship W3134260624A5041997129 @default.
• W3134260624 hasAuthorship W3134260624A5043097979 @default.
• W3134260624 hasAuthorship W3134260624A5053771070 @default.

• next