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- W3134262809 endingPage "363" @default.
- W3134262809 startingPage "363" @default.
- W3134262809 abstract "Best known as a transcriptional factor, CCCTC-binding factor (CTCF) is a highly conserved multifunctional DNA-binding protein with 11 zinc fingers. It functions in diverse genomic processes, including transcriptional activation/repression, insulation, genome imprinting and three-dimensional genome organization. A big surprise has recently emerged with the identification of CTCF engaging in the repair of DNA double-strand breaks (DSBs) and in the maintenance of genome fidelity. This discovery now adds a new dimension to the multifaceted attributes of this protein. CTCF facilitates the most accurate DSB repair via homologous recombination (HR) that occurs through an elaborate pathway, which entails a chain of timely assembly/disassembly of various HR-repair complexes and chromatin modifications and coordinates multistep HR processes to faithfully restore the original DNA sequences of broken DNA sites. Understanding the functional crosstalks between CTCF and other HR factors will illuminate the molecular basis of various human diseases that range from developmental disorders to cancer and arise from impaired repair. Such knowledge will also help understand the molecular mechanisms underlying the diverse functions of CTCF in genome biology. In this review, we discuss the recent advances regarding this newly assigned versatile role of CTCF and the mechanism whereby CTCF functions in DSB repair." @default.
- W3134262809 created "2021-03-15" @default.
- W3134262809 creator A5024610841 @default.
- W3134262809 creator A5057025466 @default.
- W3134262809 date "2021-02-27" @default.
- W3134262809 modified "2023-10-18" @default.
- W3134262809 title "A Newly Assigned Role of CTCF in Cellular Response to Broken DNAs" @default.
- W3134262809 cites W1489094157 @default.
- W3134262809 cites W1506343731 @default.
- W3134262809 cites W1521943738 @default.
- W3134262809 cites W1565385417 @default.
- W3134262809 cites W1643500256 @default.
- W3134262809 cites W1669374546 @default.
- W3134262809 cites W1966900987 @default.
- W3134262809 cites W1971625403 @default.
- W3134262809 cites W1973075378 @default.
- W3134262809 cites W1980236727 @default.
- W3134262809 cites W1981437154 @default.
- W3134262809 cites W1981816841 @default.
- W3134262809 cites W1988716393 @default.
- W3134262809 cites W1998271864 @default.
- W3134262809 cites W2004735306 @default.
- W3134262809 cites W2008722912 @default.
- W3134262809 cites W2019937806 @default.
- W3134262809 cites W2028138760 @default.
- W3134262809 cites W2029380592 @default.
- W3134262809 cites W2032522670 @default.
- W3134262809 cites W2034103505 @default.
- W3134262809 cites W2034527116 @default.
- W3134262809 cites W2036636377 @default.
- W3134262809 cites W2040681936 @default.
- W3134262809 cites W2041105606 @default.
- W3134262809 cites W2051233607 @default.
- W3134262809 cites W2052521064 @default.
- W3134262809 cites W2056406429 @default.
- W3134262809 cites W2066872364 @default.
- W3134262809 cites W2067139494 @default.
- W3134262809 cites W2070021921 @default.
- W3134262809 cites W2074906225 @default.
- W3134262809 cites W2077011077 @default.
- W3134262809 cites W2078526277 @default.
- W3134262809 cites W2084034209 @default.
- W3134262809 cites W2084212184 @default.
- W3134262809 cites W2088016816 @default.
- W3134262809 cites W2088509777 @default.
- W3134262809 cites W2091350790 @default.
- W3134262809 cites W2092992881 @default.
- W3134262809 cites W2093032186 @default.
- W3134262809 cites W2100213817 @default.
- W3134262809 cites W2116111550 @default.
- W3134262809 cites W2124037827 @default.
- W3134262809 cites W2127033140 @default.
- W3134262809 cites W2127821590 @default.
- W3134262809 cites W2136932227 @default.
- W3134262809 cites W2137186575 @default.
- W3134262809 cites W2140126848 @default.
- W3134262809 cites W2142871091 @default.
- W3134262809 cites W2150862729 @default.
- W3134262809 cites W2151925648 @default.
- W3134262809 cites W2156565413 @default.
- W3134262809 cites W2160999108 @default.
- W3134262809 cites W2161989354 @default.
- W3134262809 cites W2162134730 @default.
- W3134262809 cites W2163605769 @default.
- W3134262809 cites W2515891401 @default.
- W3134262809 cites W2593740646 @default.
- W3134262809 cites W2614144400 @default.
- W3134262809 cites W2619984498 @default.
- W3134262809 cites W2623030379 @default.
- W3134262809 cites W2737563286 @default.
- W3134262809 cites W2763540992 @default.
- W3134262809 cites W2768736041 @default.
- W3134262809 cites W2770122156 @default.
- W3134262809 cites W2770987260 @default.
- W3134262809 cites W2775505403 @default.
- W3134262809 cites W2799593901 @default.
- W3134262809 cites W2949696308 @default.
- W3134262809 cites W2952276239 @default.
- W3134262809 cites W2964054840 @default.
- W3134262809 cites W2968001579 @default.
- W3134262809 cites W2982257042 @default.
- W3134262809 cites W2998399076 @default.
- W3134262809 cites W3013793427 @default.
- W3134262809 cites W3036006733 @default.
- W3134262809 cites W3044002183 @default.
- W3134262809 cites W3106938813 @default.
- W3134262809 cites W3112120492 @default.
- W3134262809 cites W3118639017 @default.
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- W3134262809 doi "https://doi.org/10.3390/biom11030363" @default.
- W3134262809 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7997455" @default.
- W3134262809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33673494" @default.
- W3134262809 hasPublicationYear "2021" @default.
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