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• W3134262902 abstract "Significance N6-methyladenosine (m 6 A) is the most prevalent modification in eukaryotic messenger RNA (mRNA) and affects RNA metabolism including splicing, stability, and translation. The m 6 A methyltransferase complex (MTC) is responsible for generating the m 6 A modifications in mRNA; however, the regulation of m 6 A modification is still unclear. We have identified Mechanistic Target of Rapamycin Complex 1 (mTORC1) as a key regulator of MTC and demonstrate that mTORC1 can stabilize MTC via activation of the chaperonin CCT complex and upregulate m 6 A modification to promote the degradation of ATG transcripts. Thus, our study unveils an mTORC1-signaling cascade that regulates m 6 A RNA methylation and autophagy." @default.
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• W3134262902 date "2021-03-01" @default.
• W3134262902 modified "2023-10-14" @default.
• W3134262902 title "mTORC1-chaperonin CCT signaling regulates m ⁶ A RNA methylation to suppress autophagy" @default.
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• W3134262902 doi "https://doi.org/10.1073/pnas.2021945118" @default.
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