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- W3134264747 abstract "Introduction: The prognosis of patients with advanced biliary tract cancer (BTC) remains dismal, with a 5-year overall survival rate of less than 10%. Although immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of several hematological and solid tumors, controversial results have been reported in BTC. In this setting, the anti-PD-L1 inhibitor durvalumab is currently under investigation in several clinical trials as monotherapy, or in combination with other pharmacological agents.Areas covered: We offer an overview of immunotherapies for BTC, discuss recently published or presented data on durvalumab pharmacology, safety, and efficacy in the treatment of BTC and consider future research directions for the agent in this setting.Expert opinion: The promising antitumor activity shown by durvalumab in early trials warrants further investigation because it may provide more effective, much needed treatment options. The results of clinical trials of this PD-L1 inhibitor, as a monotherapy or in combination, are eagerly awaited. Future efforts should focus on the identification and development of reliable biomarkers of response to durvalumab in BTC, clarifying the role of PD-L1 expression, microsatellite instability (MSI), mismatch repair (MMR), tumor mutational burden (TMB) and other emerging predictors." @default.
- W3134264747 created "2021-03-15" @default.
- W3134264747 creator A5016268842 @default.
- W3134264747 creator A5042892518 @default.
- W3134264747 creator A5068055005 @default.
- W3134264747 date "2021-03-09" @default.
- W3134264747 modified "2023-09-29" @default.
- W3134264747 title "Durvalumab: an investigational anti-PD-L1 antibody for the treatment of biliary tract cancer" @default.
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- W3134264747 doi "https://doi.org/10.1080/13543784.2021.1897102" @default.
- W3134264747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33645367" @default.
- W3134264747 hasPublicationYear "2021" @default.
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