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- W3134264891 abstract "Abstract Noncoding RNAs (ncRNAs) are involved in various biological processes, including gene expression, development, and disease. Here, we identify a novel consensus sequence of a cis -element involved in long ncRNA (lncRNA) transcription and demonstrate that lncRNA transcription from this cis -element activates meiotic recombination via chromatin remodeling. In the fission yeast fbp1 gene, glucose starvation induces a series of promoter-associated lncRNAs, referred to as metabolic-stress-induced lncRNAs (mlonRNAs), which contribute to chromatin remodeling and fbp1 activation. Translocation of the cis -element required for mlonRNA into a well-characterized meiotic recombination hotspot, ade6-M26 , further stimulates transcription and meiotic recombination via local chromatin remodeling. The consensus sequence of this cis -element ( mlon-box ) overlaps with meiotic recombination sites in the fission yeast genome. At one such site, the SPBC24C6.09c upstream region, meiotic double-strand break (DSB) formation is induced in an mlon-box -dependent manner. Therefore, mlonRNA transcription plays a universal role in chromatin remodeling and the regulation of transcription and recombination." @default.
- W3134264891 created "2021-03-15" @default.
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- W3134264891 date "2021-03-05" @default.
- W3134264891 modified "2023-10-18" @default.
- W3134264891 title "lncRNA transcription induces meiotic recombination through chromatin remodelling in fission yeast" @default.
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- W3134264891 doi "https://doi.org/10.1038/s42003-021-01798-8" @default.
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