FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134269360> ?p ?o ?g. }

• W3134269360 endingPage "2713" @default.
• W3134269360 startingPage "2705" @default.
• W3134269360 abstract "Despite advances in targeted therapies, the prognosis for patients with triple-negative breast cancer (TNBC) is poor because there are few actionable molecular targets. The dependence of solid tumor growth on angiogenesis prompted our development of angiogenic-receptor-targeted radionuclide therapy (TRT) to treat TNBC by targeted delivery of therapeutic doses of ionizing radiation to tumors. A high-affinity vascular endothelial growth factor receptor (VEGFR)-targeted agent, diZD, was synthesized and labeled with 177Lu and 64Cu by 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator giving the TRT agent, 177Lu-DOTA-diZD, and PET imaging agent, 64Cu-DOTA-diZD. We showed that 64Cu/177Lu-DOTA-diZD radiotracers are a promising theranostic pair for TNBC. 4T1-bearing mice treated with 177Lu-DOTA-diZD-based TRT survived with a median of 28 days, which was significantly longer than that of control mice as 18 days. Anti-PD1 immunotherapy resulted in a shorter median survival of 16 days. This work presents for the first time that small-molecule VEGFR-oriented TRT is a promising therapeutic option to treat immunogenic cold TNBC." @default.
• W3134269360 created "2021-03-15" @default.
• W3134269360 creator A5026749521 @default.
• W3134269360 creator A5034711601 @default.
• W3134269360 creator A5042463866 @default.
• W3134269360 creator A5052089833 @default.
• W3134269360 creator A5054581768 @default.
• W3134269360 creator A5060335470 @default.
• W3134269360 creator A5062808645 @default.
• W3134269360 creator A5081844561 @default.
• W3134269360 date "2021-03-01" @default.
• W3134269360 modified "2023-09-25" @default.
• W3134269360 title "⁶⁴Cu/¹⁷⁷Lu-DOTA-diZD, a Small-Molecule-Based Theranostic Pair for Triple-Negative Breast Cancer" @default.
• W3134269360 cites W1774029313 @default.
• W3134269360 cites W1915663515 @default.
• W3134269360 cites W1972082925 @default.
• W3134269360 cites W1978139448 @default.
• W3134269360 cites W1987960874 @default.
• W3134269360 cites W2026861011 @default.
• W3134269360 cites W2096027508 @default.
• W3134269360 cites W2097183016 @default.
• W3134269360 cites W2099970938 @default.
• W3134269360 cites W2157229409 @default.
• W3134269360 cites W2165936545 @default.
• W3134269360 cites W2170602872 @default.
• W3134269360 cites W2173858545 @default.
• W3134269360 cites W2176372762 @default.
• W3134269360 cites W2528806911 @default.
• W3134269360 cites W2573369749 @default.
• W3134269360 cites W2614925003 @default.
• W3134269360 cites W2746995197 @default.
• W3134269360 cites W2761797827 @default.
• W3134269360 cites W2787095966 @default.
• W3134269360 cites W2791567488 @default.
• W3134269360 cites W2793323124 @default.
• W3134269360 cites W2809957686 @default.
• W3134269360 cites W2887229904 @default.
• W3134269360 cites W2887577080 @default.
• W3134269360 cites W2892869908 @default.
• W3134269360 cites W2914833937 @default.
• W3134269360 cites W2931571662 @default.
• W3134269360 cites W2970097861 @default.
• W3134269360 cites W2982475566 @default.
• W3134269360 cites W3042636067 @default.
• W3134269360 cites W4244975843 @default.
• W3134269360 doi "https://doi.org/10.1021/acs.jmedchem.0c01957" @default.
• W3134269360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33646782" @default.
• W3134269360 hasPublicationYear "2021" @default.
• W3134269360 type Work @default.
• W3134269360 sameAs 3134269360 @default.
• W3134269360 citedByCount "4" @default.
• W3134269360 countsByYear W31342693602022 @default.
• W3134269360 countsByYear W31342693602023 @default.
• W3134269360 crossrefType "journal-article" @default.
• W3134269360 hasAuthorship W3134269360A5026749521 @default.
• W3134269360 hasAuthorship W3134269360A5034711601 @default.
• W3134269360 hasAuthorship W3134269360A5042463866 @default.
• W3134269360 hasAuthorship W3134269360A5052089833 @default.
• W3134269360 hasAuthorship W3134269360A5054581768 @default.
• W3134269360 hasAuthorship W3134269360A5060335470 @default.
• W3134269360 hasAuthorship W3134269360A5062808645 @default.
• W3134269360 hasAuthorship W3134269360A5081844561 @default.
• W3134269360 hasConcept C121608353 @default.
• W3134269360 hasConcept C126322002 @default.
• W3134269360 hasConcept C161624437 @default.
• W3134269360 hasConcept C178790620 @default.
• W3134269360 hasConcept C179104552 @default.
• W3134269360 hasConcept C185592680 @default.
• W3134269360 hasConcept C197404232 @default.
• W3134269360 hasConcept C2779931791 @default.
• W3134269360 hasConcept C2780110267 @default.
• W3134269360 hasConcept C32909587 @default.
• W3134269360 hasConcept C530470458 @default.
• W3134269360 hasConcept C55493867 @default.
• W3134269360 hasConcept C71924100 @default.
• W3134269360 hasConceptScore W3134269360C121608353 @default.
• W3134269360 hasConceptScore W3134269360C126322002 @default.
• W3134269360 hasConceptScore W3134269360C161624437 @default.
• W3134269360 hasConceptScore W3134269360C178790620 @default.
• W3134269360 hasConceptScore W3134269360C179104552 @default.
• W3134269360 hasConceptScore W3134269360C185592680 @default.
• W3134269360 hasConceptScore W3134269360C197404232 @default.
• W3134269360 hasConceptScore W3134269360C2779931791 @default.
• W3134269360 hasConceptScore W3134269360C2780110267 @default.
• W3134269360 hasConceptScore W3134269360C32909587 @default.
• W3134269360 hasConceptScore W3134269360C530470458 @default.
• W3134269360 hasConceptScore W3134269360C55493867 @default.
• W3134269360 hasConceptScore W3134269360C71924100 @default.
• W3134269360 hasFunder F4320306078 @default.
• W3134269360 hasFunder F4320332513 @default.
• W3134269360 hasFunder F4320333841 @default.
• W3134269360 hasIssue "5" @default.
• W3134269360 hasLocation W31342693601 @default.
• W3134269360 hasOpenAccess W3134269360 @default.
• W3134269360 hasPrimaryLocation W31342693601 @default.
• W3134269360 hasRelatedWork W1965261620 @default.
• W3134269360 hasRelatedWork W1966181922 @default.
• W3134269360 hasRelatedWork W1981888684 @default.

• next