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- W3134312108 abstract "Enterovirus A71 (EV-A71), Coxsackievirus A16 (CV-A16) and CV-A10 are the major causative agents of hand, foot and mouth disease (HFMD). The conformational epitopes play a vital role in monitoring the antigenic evolution, predicting dominant strains and preparing vaccines. In this study, we employed a Bioinformatics-based algorithm to predict the conformational epitopes of EV-A71 and CV-A16 and compared with that of CV-A10. Prediction results revealed that the distribution patterns of conformational epitopes of EV-A71 and CV-A16 were similar to that of CV-A10 and their epitopes likewise consisted of three sites: site 1 (on the north rim of the canyon around the fivefold vertex), site 2 (on the puff) and site 3 (one part was in the knob and the other was near the threefold vertex). The reported epitopes highly overlapped with our predicted epitopes indicating the predicted results were reliable. These data suggested that three-site distribution pattern may be the basic distribution role of epitopes on the enteroviruses capsids. Our prediction results of EV-A71 and CV-A16 can provide essential information for monitoring the antigenic evolution of enterovirus." @default.
- W3134312108 created "2021-03-15" @default.
- W3134312108 creator A5001587770 @default.
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- W3134312108 date "2021-03-11" @default.
- W3134312108 modified "2023-10-17" @default.
- W3134312108 title "Bioinformatics-based prediction of conformational epitopes for Enterovirus A71 and Coxsackievirus A16" @default.
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- W3134312108 doi "https://doi.org/10.1038/s41598-021-84891-6" @default.
- W3134312108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7952546" @default.
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- W3134312108 hasPublicationYear "2021" @default.
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