Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134320912> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W3134320912 abstract "Incubation of 3T3-L1 adipocytes with insulin at 37C resulted in a 2-fold increase in transferrin binding to surface receptors, as measured by a subsequent incubation of cells at 4C with SVI-transferrin. The insulin concentration required for half-maximal effect was 10 nM, and the half-time for insulin action was 40 sec. Scatchard analysis of SVI-transferrin binding to cells at 4C showed that the insulin-induced increase in transferrin binding was due to an increase in the number of surface transferrin receptors. When cells were incubated for 2 h at 37 with SVI-transferrin to achieve steady-state binding and then exposed to insulin, there was a 2-fold increase in surface-bound transferrin and a corresponding decrease in intracellularly bound transferrin. Thus, insulin elicits translocation of intracellular transferrin receptors to the plasma membrane. Concomitant with the 2-fold increase in surface receptors in response to insulin was a 2-fold increase in the rate of VZFe uptake from VZFe-transferrin. The rate of externalization of intracellular SVI-transferrin-receptor complex at 37 was determined for basal and insulin-treated cells. Insulin increased the first-order rate constant for this process 2-fold. The effect of insulin on the rate constant for externalization is sufficient to account entirely for the increase in surface transferrin receptors." @default.
- W3134320912 created "2021-03-15" @default.
- W3134320912 creator A5013341304 @default.
- W3134320912 creator A5051198571 @default.
- W3134320912 date "1987-05-01" @default.
- W3134320912 modified "2023-09-27" @default.
- W3134320912 title "Insulin elicits a redistribution of transferrin receptors in 3T3-L1 adipocytes through an increase in the rate constant for receptor externalization" @default.
- W3134320912 hasPublicationYear "1987" @default.
- W3134320912 type Work @default.
- W3134320912 sameAs 3134320912 @default.
- W3134320912 citedByCount "0" @default.
- W3134320912 crossrefType "journal-article" @default.
- W3134320912 hasAuthorship W3134320912A5013341304 @default.
- W3134320912 hasAuthorship W3134320912A5051198571 @default.
- W3134320912 hasConcept C112446052 @default.
- W3134320912 hasConcept C126322002 @default.
- W3134320912 hasConcept C134018914 @default.
- W3134320912 hasConcept C170493617 @default.
- W3134320912 hasConcept C185592680 @default.
- W3134320912 hasConcept C22814914 @default.
- W3134320912 hasConcept C2777391703 @default.
- W3134320912 hasConcept C2779306644 @default.
- W3134320912 hasConcept C32264632 @default.
- W3134320912 hasConcept C55493867 @default.
- W3134320912 hasConcept C71924100 @default.
- W3134320912 hasConcept C79879829 @default.
- W3134320912 hasConcept C86803240 @default.
- W3134320912 hasConceptScore W3134320912C112446052 @default.
- W3134320912 hasConceptScore W3134320912C126322002 @default.
- W3134320912 hasConceptScore W3134320912C134018914 @default.
- W3134320912 hasConceptScore W3134320912C170493617 @default.
- W3134320912 hasConceptScore W3134320912C185592680 @default.
- W3134320912 hasConceptScore W3134320912C22814914 @default.
- W3134320912 hasConceptScore W3134320912C2777391703 @default.
- W3134320912 hasConceptScore W3134320912C2779306644 @default.
- W3134320912 hasConceptScore W3134320912C32264632 @default.
- W3134320912 hasConceptScore W3134320912C55493867 @default.
- W3134320912 hasConceptScore W3134320912C71924100 @default.
- W3134320912 hasConceptScore W3134320912C79879829 @default.
- W3134320912 hasConceptScore W3134320912C86803240 @default.
- W3134320912 hasLocation W31343209121 @default.
- W3134320912 hasOpenAccess W3134320912 @default.
- W3134320912 hasPrimaryLocation W31343209121 @default.
- W3134320912 hasRelatedWork W1494697908 @default.
- W3134320912 hasRelatedWork W1525646795 @default.
- W3134320912 hasRelatedWork W1525924070 @default.
- W3134320912 hasRelatedWork W1527385799 @default.
- W3134320912 hasRelatedWork W1527746711 @default.
- W3134320912 hasRelatedWork W1534628900 @default.
- W3134320912 hasRelatedWork W1577657954 @default.
- W3134320912 hasRelatedWork W1591495971 @default.
- W3134320912 hasRelatedWork W1604679503 @default.
- W3134320912 hasRelatedWork W1966008171 @default.
- W3134320912 hasRelatedWork W2018152664 @default.
- W3134320912 hasRelatedWork W2023918550 @default.
- W3134320912 hasRelatedWork W2026011300 @default.
- W3134320912 hasRelatedWork W2059135958 @default.
- W3134320912 hasRelatedWork W2082135492 @default.
- W3134320912 hasRelatedWork W2086276378 @default.
- W3134320912 hasRelatedWork W2096864633 @default.
- W3134320912 hasRelatedWork W3135889262 @default.
- W3134320912 hasRelatedWork W3198624052 @default.
- W3134320912 hasRelatedWork W3210039113 @default.
- W3134320912 isParatext "false" @default.
- W3134320912 isRetracted "false" @default.
- W3134320912 magId "3134320912" @default.
- W3134320912 workType "article" @default.