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- W3134335942 abstract "Parkinson’s disease (PD) is a condition with heterogeneous clinical manifestations that vary in age at onset, rate of progression, disease course, severity, motor and non-motor symptoms, and a variable response to antiparkinsonian drugs. It is considered that there are multiple PD etiological subtypes, some of which could be predicted by genetics. The characterization and prediction of these distinct molecular entities provides a growing opportunity to use individualized management and personalized therapies. Dissecting the genetic architecture of PD is a critical step in identifying therapeutic targets, and genetics represents a step forward to sub-categorize and predict PD risk and progression. A better understanding and separation of genetic subtypes has immediate implications in clinical trial design by unraveling the different flavors of clinical presentation and development. Personalized medicine is a nascent area of research and represents a paramount challenge in the treatment and cure of PD. This manuscript summarizes the current state of precision medicine in the PD field and discusses how genetics has become the engine to gain insights into disease during our constant effort to develop potential etiological based interventions." @default.
- W3134335942 created "2021-03-15" @default.
- W3134335942 creator A5042119624 @default.
- W3134335942 creator A5055082420 @default.
- W3134335942 creator A5055105219 @default.
- W3134335942 creator A5090792777 @default.
- W3134335942 date "2021-03-01" @default.
- W3134335942 modified "2023-09-25" @default.
- W3134335942 title "Advancing Personalized Medicine in Common Forms of Parkinson’s Disease through Genetics: Current Therapeutics and the Future of Individualized Management" @default.
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- W3134335942 doi "https://doi.org/10.3390/jpm11030169" @default.
- W3134335942 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7998972" @default.
- W3134335942 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33804504" @default.
- W3134335942 hasPublicationYear "2021" @default.
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