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- W3134344866 abstract "Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil-derived reactive oxygen species (ROS) and granule proteases are implicated in damage to and destruction of host tissues in both conditions (cartilage in RA, vascular tissue in SLE) and also in the pathogenic post-translational modification of DNA and proteins. Neutrophil-derived cytokines and chemokines regulate both the innate and adaptive immune responses in RA and SLE, and neutrophil extracellular traps (NETs) expose nuclear neoepitopes (citrullinated proteins in RA, double-stranded DNA and nuclear proteins in SLE) to the immune system, initiating the production of auto-antibodies (ACPA in RA, anti-dsDNA and anti-acetylated/methylated histones in SLE). Neutrophil apoptosis is dysregulated in both conditions: in RA, delayed apoptosis within synovial joints contributes to chronic inflammation, immune cell recruitment and prolonged release of proteolytic enzymes, whereas in SLE enhanced apoptosis leads to increased apoptotic burden associated with development of anti-nuclear auto-antibodies. An unbalanced energy metabolism in SLE and RA neutrophils contributes to the pathology of both diseases; increased hypoxia and glycolysis in RA drives neutrophil activation and NET production, whereas decreased redox capacity increases ROS-mediated damage in SLE. Neutrophil low-density granulocytes (LDGs), present in high numbers in the blood of both RA and SLE patients, have opposing phenotypes contributing to clinical manifestations of each disease. In this review we will describe the complex and contrasting phenotype of neutrophils and LDGs in RA and SLE and discuss their discrete roles in the pathogenesis of each condition. We will also review our current understanding of transcriptomic and metabolomic regulation of neutrophil phenotype in RA and SLE and discuss opportunities for therapeutic targeting of neutrophil activation in inflammatory auto-immune disease." @default.
- W3134344866 created "2021-03-15" @default.
- W3134344866 creator A5022176644 @default.
- W3134344866 creator A5031073125 @default.
- W3134344866 creator A5078491446 @default.
- W3134344866 date "2021-03-04" @default.
- W3134344866 modified "2023-10-17" @default.
- W3134344866 title "Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different M.O." @default.
- W3134344866 cites W1216511763 @default.
- W3134344866 cites W135255393 @default.
- W3134344866 cites W1480967651 @default.
- W3134344866 cites W1499792579 @default.
- W3134344866 cites W1508837702 @default.
- W3134344866 cites W1532795681 @default.
- W3134344866 cites W1543475519 @default.
- W3134344866 cites W1564279536 @default.
- W3134344866 cites W1564442291 @default.
- W3134344866 cites W1572142897 @default.
- W3134344866 cites W1572925458 @default.
- W3134344866 cites W1591429036 @default.
- W3134344866 cites W1597610606 @default.
- W3134344866 cites W1606309125 @default.
- W3134344866 cites W1639439016 @default.
- W3134344866 cites W174840698 @default.
- W3134344866 cites W1755717066 @default.
- W3134344866 cites W1846965874 @default.
- W3134344866 cites W1879615281 @default.
- W3134344866 cites W1891774658 @default.
- W3134344866 cites W1898478495 @default.
- W3134344866 cites W1904085974 @default.
- W3134344866 cites W1962263634 @default.
- W3134344866 cites W1968813300 @default.
- W3134344866 cites W1969152259 @default.
- W3134344866 cites W1969468689 @default.
- W3134344866 cites W1970567270 @default.
- W3134344866 cites W1972437914 @default.
- W3134344866 cites W1973192479 @default.
- W3134344866 cites W1973628719 @default.
- W3134344866 cites W1974070644 @default.
- W3134344866 cites W1975118457 @default.
- W3134344866 cites W1976646654 @default.
- W3134344866 cites W1978172024 @default.
- W3134344866 cites W1978366083 @default.
- W3134344866 cites W1979098269 @default.
- W3134344866 cites W1979790110 @default.
- W3134344866 cites W1980856393 @default.
- W3134344866 cites W1981664222 @default.
- W3134344866 cites W1983075934 @default.
- W3134344866 cites W1984839364 @default.
- W3134344866 cites W1986508855 @default.
- W3134344866 cites W1989590412 @default.
- W3134344866 cites W1992540248 @default.
- W3134344866 cites W1992687368 @default.
- W3134344866 cites W1993823752 @default.
- W3134344866 cites W1996254162 @default.
- W3134344866 cites W1996688998 @default.
- W3134344866 cites W1998336889 @default.
- W3134344866 cites W1998653249 @default.
- W3134344866 cites W2002157461 @default.
- W3134344866 cites W2002394482 @default.
- W3134344866 cites W2005739235 @default.
- W3134344866 cites W2007163703 @default.
- W3134344866 cites W2007493927 @default.
- W3134344866 cites W2008586755 @default.
- W3134344866 cites W2012766752 @default.
- W3134344866 cites W2013173405 @default.
- W3134344866 cites W2015762143 @default.
- W3134344866 cites W2016186074 @default.
- W3134344866 cites W2017338571 @default.
- W3134344866 cites W2017870766 @default.
- W3134344866 cites W2019916852 @default.
- W3134344866 cites W2021221986 @default.
- W3134344866 cites W2023826150 @default.
- W3134344866 cites W2024216850 @default.
- W3134344866 cites W2027734621 @default.
- W3134344866 cites W2028543411 @default.
- W3134344866 cites W2029617490 @default.
- W3134344866 cites W2030432162 @default.
- W3134344866 cites W2031084334 @default.
- W3134344866 cites W2031111964 @default.
- W3134344866 cites W2032474910 @default.
- W3134344866 cites W2033618609 @default.
- W3134344866 cites W2033753616 @default.
- W3134344866 cites W2039002046 @default.
- W3134344866 cites W2043069574 @default.
- W3134344866 cites W2043314695 @default.
- W3134344866 cites W2046973175 @default.
- W3134344866 cites W2049736324 @default.
- W3134344866 cites W2056317605 @default.
- W3134344866 cites W2058692268 @default.
- W3134344866 cites W2060228585 @default.
- W3134344866 cites W2062872171 @default.
- W3134344866 cites W2064070262 @default.
- W3134344866 cites W2064353276 @default.
- W3134344866 cites W2066461571 @default.
- W3134344866 cites W2067022007 @default.
- W3134344866 cites W2067184583 @default.
- W3134344866 cites W2071153137 @default.
- W3134344866 cites W2071439363 @default.
- W3134344866 cites W2072322888 @default.