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- W3134355526 endingPage "2482" @default.
- W3134355526 startingPage "2482" @default.
- W3134355526 abstract "The nucleoli are membrane-less nuclear substructures that govern ribosome biogenesis and participate in multiple other cellular processes such as cell cycle progression, stress sensing, and DNA damage response. The proper functioning of these organelles is ensured by specific proteins that maintain nucleolar structure and mediate key nucleolar activities. Among all nucleolar proteins, treacle encoded by TCOF1 gene emerges as one of the most crucial regulators of cellular processes. TCOF1 was initially discovered as a gene involved in the Treacher Collins syndrome, a rare genetic disorder characterized by severe craniofacial deformations. Later studies revealed that treacle regulates ribosome biogenesis, mitosis, proliferation, DNA damage response, and apoptosis. Importantly, several reports indicate that treacle is also involved in cancer development, progression, and response to therapies, and may contribute to other pathologies such as Hirschsprung disease. In this manuscript, we comprehensively review the structure, function, and the regulation of TCOF1/treacle in physiological and pathological processes." @default.
- W3134355526 created "2021-03-15" @default.
- W3134355526 creator A5013835656 @default.
- W3134355526 creator A5090743345 @default.
- W3134355526 date "2021-03-01" @default.
- W3134355526 modified "2023-10-16" @default.
- W3134355526 title "The Role of TCOF1 Gene in Health and Disease: Beyond Treacher Collins Syndrome" @default.
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