Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134357072> ?p ?o ?g. }
- W3134357072 endingPage "1093" @default.
- W3134357072 startingPage "1093" @default.
- W3134357072 abstract "Hypoxia in the tumor microenvironment is a negative prognostic factor associated with tumor progression and metastasis, and therefore represents an attractive therapeutic target for anti-tumor therapy. To test the effectiveness of novel hypoxia-targeting drugs, appropriate preclinical models that recreate tumor hypoxia are essential. The chicken ChorioAllantoic Membrane (CAM) assay is increasingly used as a rapid cost-effective in vivo drug-testing platform that recapitulates many aspects of human cancers. However, it remains to be determined whether this model recreates the hypoxic microenvironment of solid tumors. To detect hypoxia in the CAM model, the hypoxic marker pimonidazole was injected into the vasculature of tumor-bearing CAM, and hypoxia-dependent gene expression was analyzed. We observed that the CAM model effectively supports the development of hypoxic zones in a variety of human tumor cell line-derived and patient’s tumor fragment-derived xenografts. The treatment of both patient and cell line-derived CAM xenografts with modulators of angiogenesis significantly altered the formation of hypoxic zones within the xenografts. Furthermore, the changes in hypoxia translated into modulated levels of chick liver metastasis as measured by Alu-based assay. These findings demonstrate that the CAM xenograft model is a valuable in vivo platform for studying hypoxia that could facilitate the identification and testing of drugs targeting this tumor microenvironment." @default.
- W3134357072 created "2021-03-15" @default.
- W3134357072 creator A5017890143 @default.
- W3134357072 creator A5019500868 @default.
- W3134357072 creator A5023385808 @default.
- W3134357072 creator A5029285947 @default.
- W3134357072 creator A5040576638 @default.
- W3134357072 creator A5067413666 @default.
- W3134357072 creator A5083779633 @default.
- W3134357072 creator A5091284963 @default.
- W3134357072 date "2021-03-04" @default.
- W3134357072 modified "2023-10-16" @default.
- W3134357072 title "The Chicken Chorioallantoic Membrane Tumor Assay as a Relevant In Vivo Model to Study the Impact of Hypoxia on Tumor Progression and Metastasis" @default.
- W3134357072 cites W10381981 @default.
- W3134357072 cites W1509592700 @default.
- W3134357072 cites W1510386426 @default.
- W3134357072 cites W1520542598 @default.
- W3134357072 cites W1964556827 @default.
- W3134357072 cites W1968259548 @default.
- W3134357072 cites W1971797342 @default.
- W3134357072 cites W1972950436 @default.
- W3134357072 cites W1976572639 @default.
- W3134357072 cites W1980475208 @default.
- W3134357072 cites W1985039814 @default.
- W3134357072 cites W1985801265 @default.
- W3134357072 cites W1989800672 @default.
- W3134357072 cites W2003667308 @default.
- W3134357072 cites W2017565497 @default.
- W3134357072 cites W2019158777 @default.
- W3134357072 cites W2019602861 @default.
- W3134357072 cites W2021228441 @default.
- W3134357072 cites W2038186795 @default.
- W3134357072 cites W2042300051 @default.
- W3134357072 cites W2044149912 @default.
- W3134357072 cites W2049382181 @default.
- W3134357072 cites W2054633892 @default.
- W3134357072 cites W2066995877 @default.
- W3134357072 cites W2075162479 @default.
- W3134357072 cites W2077501711 @default.
- W3134357072 cites W2077943385 @default.
- W3134357072 cites W2084486398 @default.
- W3134357072 cites W2084773521 @default.
- W3134357072 cites W2085765058 @default.
- W3134357072 cites W2085815730 @default.
- W3134357072 cites W2087772688 @default.
- W3134357072 cites W2103689170 @default.
- W3134357072 cites W2108189797 @default.
- W3134357072 cites W2109294354 @default.
- W3134357072 cites W2113836212 @default.
- W3134357072 cites W2118655588 @default.
- W3134357072 cites W2123894943 @default.
- W3134357072 cites W2132719707 @default.
- W3134357072 cites W2136808951 @default.
- W3134357072 cites W2139439558 @default.
- W3134357072 cites W2143142619 @default.
- W3134357072 cites W2153584531 @default.
- W3134357072 cites W2204695292 @default.
- W3134357072 cites W2254833392 @default.
- W3134357072 cites W2255357451 @default.
- W3134357072 cites W2323751645 @default.
- W3134357072 cites W2327922861 @default.
- W3134357072 cites W2383968316 @default.
- W3134357072 cites W2415902903 @default.
- W3134357072 cites W2560333590 @default.
- W3134357072 cites W2613973024 @default.
- W3134357072 cites W2619008941 @default.
- W3134357072 cites W2623685580 @default.
- W3134357072 cites W2692981981 @default.
- W3134357072 cites W2754871120 @default.
- W3134357072 cites W2770335189 @default.
- W3134357072 cites W2782483649 @default.
- W3134357072 cites W2791469985 @default.
- W3134357072 cites W2806233947 @default.
- W3134357072 cites W2883962865 @default.
- W3134357072 cites W2944398260 @default.
- W3134357072 cites W2947856563 @default.
- W3134357072 cites W2953807958 @default.
- W3134357072 cites W3006011311 @default.
- W3134357072 cites W3012240350 @default.
- W3134357072 cites W3023681985 @default.
- W3134357072 cites W3091992458 @default.
- W3134357072 cites W335253295 @default.
- W3134357072 cites W4362223593 @default.
- W3134357072 doi "https://doi.org/10.3390/cancers13051093" @default.
- W3134357072 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7961795" @default.
- W3134357072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33806378" @default.
- W3134357072 hasPublicationYear "2021" @default.
- W3134357072 type Work @default.
- W3134357072 sameAs 3134357072 @default.
- W3134357072 citedByCount "12" @default.
- W3134357072 countsByYear W31343570722021 @default.
- W3134357072 countsByYear W31343570722022 @default.
- W3134357072 countsByYear W31343570722023 @default.
- W3134357072 crossrefType "journal-article" @default.
- W3134357072 hasAuthorship W3134357072A5017890143 @default.
- W3134357072 hasAuthorship W3134357072A5019500868 @default.
- W3134357072 hasAuthorship W3134357072A5023385808 @default.
- W3134357072 hasAuthorship W3134357072A5029285947 @default.