FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134361734> ?p ?o ?g. }

• W3134361734 endingPage "2551" @default.
• W3134361734 startingPage "2551" @default.
• W3134361734 abstract "Coeliac disease (CD) is a clinically heterogeneous autoimmune disease with variable presentation and progression triggered by gluten intake. Molecular or genetic factors contribute to disease heterogeneity, but the reasons for different outcomes are poorly understood. Transcriptome studies of tissue biopsies from CD patients are scarce. Here, we present a high-resolution analysis of the transcriptomes extracted from duodenal biopsies of 24 children and adolescents with active CD and 21 individuals without CD but with intestinal afflictions as controls. The transcriptomes of CD patients divide into three groups—a mixed group presenting the control cases, and CD-low and CD-high groups referring to lower and higher levels of CD severity. Persistence of symptoms was weakly associated with subgroup, but the highest marsh stages were present in subgroup CD-high, together with the highest cell cycle rates as an indicator of virtually complete villous atrophy. Considerable variation in inflammation-level between subgroups was further deciphered into immune cell types using cell type de-convolution. Self-organizing maps portrayal was applied to provide high-resolution landscapes of the CD-transcriptome. We find asymmetric patterns of miRNA and long non-coding RNA and discuss the effect of epigenetic regulation. Expression of genes involved in interferon gamma signaling represent suitable markers to distinguish CD from non-CD cases. Multiple pathways overlay in CD biopsies in different ways, giving rise to heterogeneous transcriptional patterns, which potentially provide information about etiology and the course of the disease." @default.
• W3134361734 created "2021-03-15" @default.
• W3134361734 creator A5000309688 @default.
• W3134361734 creator A5017979636 @default.
• W3134361734 creator A5025059319 @default.
• W3134361734 creator A5045754538 @default.
• W3134361734 creator A5060754809 @default.
• W3134361734 creator A5063145847 @default.
• W3134361734 creator A5065441188 @default.
• W3134361734 creator A5068480255 @default.
• W3134361734 creator A5076005625 @default.
• W3134361734 date "2021-03-04" @default.
• W3134361734 modified "2023-10-04" @default.
• W3134361734 title "Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies" @default.
• W3134361734 cites W1488442803 @default.
• W3134361734 cites W1755551634 @default.
• W3134361734 cites W1966603003 @default.
• W3134361734 cites W1985987855 @default.
• W3134361734 cites W1989619485 @default.
• W3134361734 cites W1995773697 @default.
• W3134361734 cites W2018515533 @default.
• W3134361734 cites W2027512162 @default.
• W3134361734 cites W2037900813 @default.
• W3134361734 cites W2043513827 @default.
• W3134361734 cites W2048796508 @default.
• W3134361734 cites W2053405945 @default.
• W3134361734 cites W2057271458 @default.
• W3134361734 cites W2059911584 @default.
• W3134361734 cites W2069642599 @default.
• W3134361734 cites W2073759231 @default.
• W3134361734 cites W2079983771 @default.
• W3134361734 cites W2080985727 @default.
• W3134361734 cites W2084922679 @default.
• W3134361734 cites W2085316529 @default.
• W3134361734 cites W2089573250 @default.
• W3134361734 cites W2099621055 @default.
• W3134361734 cites W2112409097 @default.
• W3134361734 cites W2115444345 @default.
• W3134361734 cites W2117391818 @default.
• W3134361734 cites W2130410032 @default.
• W3134361734 cites W2139696807 @default.
• W3134361734 cites W2142777830 @default.
• W3134361734 cites W2147569164 @default.
• W3134361734 cites W2151937508 @default.
• W3134361734 cites W2153031009 @default.
• W3134361734 cites W2154589460 @default.
• W3134361734 cites W2156674292 @default.
• W3134361734 cites W2164504476 @default.
• W3134361734 cites W2165165394 @default.
• W3134361734 cites W2187457761 @default.
• W3134361734 cites W2214074259 @default.
• W3134361734 cites W2271177740 @default.
• W3134361734 cites W2344533461 @default.
• W3134361734 cites W2415725738 @default.
• W3134361734 cites W2549109973 @default.
• W3134361734 cites W2584563445 @default.
• W3134361734 cites W2603727659 @default.
• W3134361734 cites W2607714548 @default.
• W3134361734 cites W2748859027 @default.
• W3134361734 cites W2751819757 @default.
• W3134361734 cites W2790479378 @default.
• W3134361734 cites W2792440444 @default.
• W3134361734 cites W2804960176 @default.
• W3134361734 cites W2808421274 @default.
• W3134361734 cites W2810734860 @default.
• W3134361734 cites W2866450277 @default.
• W3134361734 cites W2883104035 @default.
• W3134361734 cites W2887754327 @default.
• W3134361734 cites W2888164765 @default.
• W3134361734 cites W2898500302 @default.
• W3134361734 cites W2920381113 @default.
• W3134361734 cites W2945471311 @default.
• W3134361734 cites W2947749131 @default.
• W3134361734 cites W2965601168 @default.
• W3134361734 cites W2973568916 @default.
• W3134361734 cites W2981393920 @default.
• W3134361734 cites W2988538746 @default.
• W3134361734 cites W2988979932 @default.
• W3134361734 cites W3046905536 @default.
• W3134361734 cites W3092689327 @default.
• W3134361734 cites W3096936586 @default.
• W3134361734 cites W3104030362 @default.
• W3134361734 cites W990667364 @default.
• W3134361734 doi "https://doi.org/10.3390/ijms22052551" @default.
• W3134361734 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7961974" @default.
• W3134361734 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33806322" @default.
• W3134361734 hasPublicationYear "2021" @default.
• W3134361734 type Work @default.
• W3134361734 sameAs 3134361734 @default.
• W3134361734 citedByCount "9" @default.
• W3134361734 countsByYear W31343617342021 @default.
• W3134361734 countsByYear W31343617342022 @default.
• W3134361734 countsByYear W31343617342023 @default.
• W3134361734 crossrefType "journal-article" @default.
• W3134361734 hasAuthorship W3134361734A5000309688 @default.
• W3134361734 hasAuthorship W3134361734A5017979636 @default.
• W3134361734 hasAuthorship W3134361734A5025059319 @default.
• W3134361734 hasAuthorship W3134361734A5045754538 @default.

• next