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• W3134373580 abstract "A 3-year-old castrated male ferret was suspected to have lymphoma based on a markedly enlarged mesenteric lymph node. Hodgkin’s-like lymphoma (HLL) was suspected because numerous Reed-Sternberg-like cells were observed in the fine-needle aspiration biopsy of the mesenteric lymph node. In the post-mortem histopathology, neoplastic cells were invasively proliferated not only in the mesenteric lymph nodes, but also in the liver and spleen. Immunohistochemically, most neoplastic cells were positive for vimentin and BLA-36, weakly positive for CD20, and negative for Pax5, CD79a, CD3, CD45, and Iba-1, demonstrating similarity to human Hodgkin’s lymphoma (HL). In addition, a prominent programmed cell death protein 1 (PD-1) expression was observed at the sites showing malignant tumour proliferation. HLL in non-human beings can be morphologically and immunophenotypically similar to human HL, but the prognosis and clinical outcome may differ. This is the first study analysing the PD-1 expression in a ferret, suggesting that PD-1 can be a novel diagnostic and prognostic factor in a similar manner to humans." @default.
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• W3134373580 date "2021-05-31" @default.
• W3134373580 modified "2023-10-18" @default.
• W3134373580 title "Aggressive behaviour of Hodgkin's-like lymphoma in a domestic ferret" @default.
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• W3134373580 doi "https://doi.org/10.17221/115/2020-vetmed" @default.
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