FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134389923> ?p ?o ?g. }

• W3134389923 endingPage "6221" @default.
• W3134389923 startingPage "6212" @default.
• W3134389923 abstract "Increasing acetate and β-hydroxybutyrate (BHB) supply to lactating cows will increase milk fat synthesis. However, the underlying molecular mechanism remains largely unknown. Cell death-inducing DNA fragmentation factor-α-like effector C (CIDEC) is a lipid droplet-associated protein that promotes intracellular triacylglycerol accumulation. In the present study, using gene overexpression and knockdown, we detected the contributions of CIDEC on milk fat synthesis in mammary epithelial cells of dairy cows in the presence of acetate and BHB. The results showed that knockdown of CIDEC decreased fatty acid synthase (FASN) expression and intracellular triacylglycerol content, whereas overexpression of CIDEC had the opposite effect. The transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) regulates cell growth and differentiation in the mammary gland. We demonstrated that the FASN promoter had a canonical C/EBPβ binding sequence. CEBPB overexpression upregulated FASN expression and milk fat synthesis, whereas CEBPB knockdown had the opposite effect. Moreover, knockdown of CEBPB attenuated the promoting effects of CIDEC on acetate- and BHB-induced FASN transcription. Taken together, our data showed that acetate and BHB induced FASN expression in mammary epithelial cells of dairy cows in a CIDEC-C/EBPβ-dependent manner, which provides new insights into the understanding of the molecular events involved in milk fat synthesis." @default.
• W3134389923 created "2021-03-15" @default.
• W3134389923 creator A5056969176 @default.
• W3134389923 creator A5067745458 @default.
• W3134389923 creator A5074055308 @default.
• W3134389923 creator A5075726242 @default.
• W3134389923 creator A5083380820 @default.
• W3134389923 creator A5084936911 @default.
• W3134389923 date "2021-05-01" @default.
• W3134389923 modified "2023-10-17" @default.
• W3134389923 title "Cell death-inducing DNA fragmentation factor-α-like effector C (CIDEC) regulates acetate- and β-hydroxybutyrate-induced milk fat synthesis by increasing FASN expression in mammary epithelial cells of dairy cows" @default.
• W3134389923 cites W128015626 @default.
• W3134389923 cites W1970382695 @default.
• W3134389923 cites W1977801817 @default.
• W3134389923 cites W1990100164 @default.
• W3134389923 cites W1994583646 @default.
• W3134389923 cites W2000002411 @default.
• W3134389923 cites W2007663002 @default.
• W3134389923 cites W2032905332 @default.
• W3134389923 cites W2034143707 @default.
• W3134389923 cites W2039252539 @default.
• W3134389923 cites W2044575601 @default.
• W3134389923 cites W2053584805 @default.
• W3134389923 cites W2054114265 @default.
• W3134389923 cites W2065910035 @default.
• W3134389923 cites W2072551674 @default.
• W3134389923 cites W2078998776 @default.
• W3134389923 cites W2097497704 @default.
• W3134389923 cites W2098974513 @default.
• W3134389923 cites W2114570899 @default.
• W3134389923 cites W2114872517 @default.
• W3134389923 cites W2128517000 @default.
• W3134389923 cites W2129011493 @default.
• W3134389923 cites W2137320377 @default.
• W3134389923 cites W2145399933 @default.
• W3134389923 cites W2155549511 @default.
• W3134389923 cites W2162522025 @default.
• W3134389923 cites W2166992789 @default.
• W3134389923 cites W2171488110 @default.
• W3134389923 cites W2188705140 @default.
• W3134389923 cites W2476581315 @default.
• W3134389923 cites W2592990477 @default.
• W3134389923 cites W2599969276 @default.
• W3134389923 cites W2773326605 @default.
• W3134389923 cites W32076058 @default.
• W3134389923 doi "https://doi.org/10.3168/jds.2020-18975" @default.
• W3134389923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33663853" @default.
• W3134389923 hasPublicationYear "2021" @default.
• W3134389923 type Work @default.
• W3134389923 sameAs 3134389923 @default.
• W3134389923 citedByCount "3" @default.
• W3134389923 countsByYear W31343899232022 @default.
• W3134389923 crossrefType "journal-article" @default.
• W3134389923 hasAuthorship W3134389923A5056969176 @default.
• W3134389923 hasAuthorship W3134389923A5067745458 @default.
• W3134389923 hasAuthorship W3134389923A5074055308 @default.
• W3134389923 hasAuthorship W3134389923A5075726242 @default.
• W3134389923 hasAuthorship W3134389923A5083380820 @default.
• W3134389923 hasAuthorship W3134389923A5084936911 @default.
• W3134389923 hasBestOaLocation W31343899231 @default.
• W3134389923 hasConcept C104317684 @default.
• W3134389923 hasConcept C121608353 @default.
• W3134389923 hasConcept C126322002 @default.
• W3134389923 hasConcept C134018914 @default.
• W3134389923 hasConcept C141359234 @default.
• W3134389923 hasConcept C153911025 @default.
• W3134389923 hasConcept C173396325 @default.
• W3134389923 hasConcept C185592680 @default.
• W3134389923 hasConcept C2778001805 @default.
• W3134389923 hasConcept C4733338 @default.
• W3134389923 hasConcept C48289651 @default.
• W3134389923 hasConcept C51785407 @default.
• W3134389923 hasConcept C530470458 @default.
• W3134389923 hasConcept C54355233 @default.
• W3134389923 hasConcept C55493867 @default.
• W3134389923 hasConcept C71924100 @default.
• W3134389923 hasConcept C86339819 @default.
• W3134389923 hasConcept C86803240 @default.
• W3134389923 hasConcept C95444343 @default.
• W3134389923 hasConceptScore W3134389923C104317684 @default.
• W3134389923 hasConceptScore W3134389923C121608353 @default.
• W3134389923 hasConceptScore W3134389923C126322002 @default.
• W3134389923 hasConceptScore W3134389923C134018914 @default.
• W3134389923 hasConceptScore W3134389923C141359234 @default.
• W3134389923 hasConceptScore W3134389923C153911025 @default.
• W3134389923 hasConceptScore W3134389923C173396325 @default.
• W3134389923 hasConceptScore W3134389923C185592680 @default.
• W3134389923 hasConceptScore W3134389923C2778001805 @default.
• W3134389923 hasConceptScore W3134389923C4733338 @default.
• W3134389923 hasConceptScore W3134389923C48289651 @default.
• W3134389923 hasConceptScore W3134389923C51785407 @default.
• W3134389923 hasConceptScore W3134389923C530470458 @default.
• W3134389923 hasConceptScore W3134389923C54355233 @default.
• W3134389923 hasConceptScore W3134389923C55493867 @default.
• W3134389923 hasConceptScore W3134389923C71924100 @default.
• W3134389923 hasConceptScore W3134389923C86339819 @default.
• W3134389923 hasConceptScore W3134389923C86803240 @default.
• W3134389923 hasConceptScore W3134389923C95444343 @default.

• next