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- W3134393256 abstract "Introduction: Hyperlipidemia is abnormal of lipid metabolism that presents in the bloodstream. The study aims is to investigate the effects on a combination mixture of Zinger officinale, Allium sativum, Citrus lemon, honey, and Malus domestica vinegar (ZACA) in rats fed with high cholesterol diet (HCD). Method: 36 male Sprague dawley rats were divided into 6 groups. ZACA extracts (1mg/kg, 3 mg/kg, 5 mg/kg of bodyweight) were administered along with high cholesterol diet (HCD) for 18 weeks. Simvastatin 10 mg/kg of bodyweight was used as a control. Results: In vitro; ZACA extracts had oxygen radical absorbance capacity (ORAC) of 2000 µmol TE/100 mL, total phenolic content (TPC) is 7537 ± 54.5%, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity is 27.34 ± 2.71% , Elastase inhibitory assay is (29.29 ± 1.65% and lipoxygenase inhibitory assay is 98.58 ± 1.42%. The high performance liquid chromatography (HPLC) detected the presence of Hesperidin in ZACA extract that acts as anti-oxidative and anti-inflammatory agent. In vivo; ZACA extract decreased bodyweight, adipose tissue weight, and improved lipid profiles (total cholesterol, triglycerides, low density lipoprotein, and high density lipoprotein). Conclusion: The results demonstrate that ZACA extracts have a protective effect against hyperlipidemia and beneficial as dietary supplement." @default.
- W3134393256 created "2021-03-15" @default.
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- W3134393256 date "2020-11-03" @default.
- W3134393256 modified "2023-09-26" @default.
- W3134393256 title "POTENTIAL EFFECTS ON A COMBINATION OF <em>ZINGER OFFICINALE, ALLIUM SATIVUM, CITRUS LEMON</em>, HONEY, AND <em>MALUS DOMESTICA</em> VINEGAR (ZACA) EXTRACT IN RATS FED WITH HIGH CHOLESTEROL DIET" @default.
- W3134393256 doi "https://doi.org/10.3390/iecn2020-07171" @default.
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