FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134401905> ?p ?o ?g. }

• W3134401905 abstract "Nuclear receptors are important bridges between lipid signaling molecules and transcription responses. Beside their role in several developmental and physiological processes, many of these receptors have been shown to regulate and determine the fate of immune cells, and the outcome of immune responses under physiological and pathological conditions. While NLRP3 inflammasome is assumed as key regulator for innate and adaptive immune responses, and has been associated with various pathological events, the precise impact of the nuclear receptors on the function of inflammasome is hardly investigated. A wide variety of factors and conditions have been identified as modulators of NLRP3 inflammasome activation, and at the same time, many of the nuclear receptors are known to regulate, and interact with these factors, including cellular metabolism and various signaling pathways. Nuclear receptors are in the focus of many researches, as these receptors are easy to manipulate by lipid soluble molecules. Importantly, nuclear receptors mediate regulatory mechanisms at multiple levels: not only at transcription level, but also in the cytosol via non-genomic effects. Their importance is also reflected by the numerous approved drugs that have been developed in the past decade to specifically target nuclear receptors subtypes. Researches aiming to delineate mechanisms that regulate NLRP3 inflammasome activation draw a wide range of attention due to their unquestionable importance in infectious and sterile inflammatory conditions. In this review, we provide an overview of current reports and knowledge about NLRP3 inflammasome regulation from the perspective of nuclear receptors, in order to bring new insight to the potentially therapeutic aspect in targeting NLRP3 inflammasome and NLRP3 inflammasome-associated diseases." @default.
• W3134401905 created "2021-03-15" @default.
• W3134401905 creator A5059640482 @default.
• W3134401905 creator A5073445040 @default.
• W3134401905 date "2021-02-26" @default.
• W3134401905 modified "2023-10-10" @default.
• W3134401905 title "Nuclear Receptors as Multiple Regulators of NLRP3 Inflammasome Function" @default.
• W3134401905 cites W1508907001 @default.
• W3134401905 cites W1561041814 @default.
• W3134401905 cites W1566509180 @default.
• W3134401905 cites W1567127662 @default.
• W3134401905 cites W1608005125 @default.
• W3134401905 cites W1633340712 @default.
• W3134401905 cites W1639924204 @default.
• W3134401905 cites W1667397546 @default.
• W3134401905 cites W1964247670 @default.
• W3134401905 cites W1967286688 @default.
• W3134401905 cites W1967896870 @default.
• W3134401905 cites W1970124511 @default.
• W3134401905 cites W1970964725 @default.
• W3134401905 cites W1971633703 @default.
• W3134401905 cites W1972571170 @default.
• W3134401905 cites W1972697674 @default.
• W3134401905 cites W1974555331 @default.
• W3134401905 cites W1981873124 @default.
• W3134401905 cites W1982872296 @default.
• W3134401905 cites W1984391988 @default.
• W3134401905 cites W1988073855 @default.
• W3134401905 cites W1989665685 @default.
• W3134401905 cites W1990920221 @default.
• W3134401905 cites W1992438813 @default.
• W3134401905 cites W1995277882 @default.
• W3134401905 cites W1998522372 @default.
• W3134401905 cites W1998585946 @default.
• W3134401905 cites W2002757138 @default.
• W3134401905 cites W2003115027 @default.
• W3134401905 cites W2009170266 @default.
• W3134401905 cites W2009337706 @default.
• W3134401905 cites W2009938323 @default.
• W3134401905 cites W2010788519 @default.
• W3134401905 cites W2014517366 @default.
• W3134401905 cites W2017011351 @default.
• W3134401905 cites W2017671227 @default.
• W3134401905 cites W2017948700 @default.
• W3134401905 cites W2018938924 @default.
• W3134401905 cites W2021879996 @default.
• W3134401905 cites W2021884650 @default.
• W3134401905 cites W2022279737 @default.
• W3134401905 cites W2023459898 @default.
• W3134401905 cites W2025165872 @default.
• W3134401905 cites W2027768860 @default.
• W3134401905 cites W2029177106 @default.
• W3134401905 cites W2032370476 @default.
• W3134401905 cites W2032693719 @default.
• W3134401905 cites W2036940526 @default.
• W3134401905 cites W2049140005 @default.
• W3134401905 cites W2051303794 @default.
• W3134401905 cites W2053186448 @default.
• W3134401905 cites W2055110899 @default.
• W3134401905 cites W2055745016 @default.
• W3134401905 cites W2056048638 @default.
• W3134401905 cites W2056707130 @default.
• W3134401905 cites W2058205407 @default.
• W3134401905 cites W2058690999 @default.
• W3134401905 cites W2061157014 @default.
• W3134401905 cites W2062091761 @default.
• W3134401905 cites W2062817574 @default.
• W3134401905 cites W2064173000 @default.
• W3134401905 cites W2064455987 @default.
• W3134401905 cites W2066662062 @default.
• W3134401905 cites W2070064125 @default.
• W3134401905 cites W2072822958 @default.
• W3134401905 cites W2073875167 @default.
• W3134401905 cites W2074448653 @default.
• W3134401905 cites W2076524169 @default.
• W3134401905 cites W2078268792 @default.
• W3134401905 cites W2078850432 @default.
• W3134401905 cites W2079724669 @default.
• W3134401905 cites W2080034730 @default.
• W3134401905 cites W2080598208 @default.
• W3134401905 cites W2082400315 @default.
• W3134401905 cites W2083668079 @default.
• W3134401905 cites W2085698365 @default.
• W3134401905 cites W2086635120 @default.
• W3134401905 cites W2086683854 @default.
• W3134401905 cites W2086911772 @default.
• W3134401905 cites W2087647782 @default.
• W3134401905 cites W2093296161 @default.
• W3134401905 cites W2098371880 @default.
• W3134401905 cites W2102459969 @default.
• W3134401905 cites W2102676295 @default.
• W3134401905 cites W2103136723 @default.
• W3134401905 cites W2103185024 @default.
• W3134401905 cites W2108414919 @default.
• W3134401905 cites W2109279065 @default.
• W3134401905 cites W2110698458 @default.
• W3134401905 cites W2112802262 @default.
• W3134401905 cites W2119369011 @default.
• W3134401905 cites W2120697418 @default.
• W3134401905 cites W2122008165 @default.

• next