Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134408072> ?p ?o ?g. }
- W3134408072 abstract "Abstract Children typically experience more mild symptoms of COVID-19 when compared to adults. There is a strong body of evidence that children are also less susceptible to SARS-CoV-2 infection with the ancestral viral isolate. However, the emergence of SARS-CoV-2 variants of concern (VOCs) has been associated with an increased number of pediatric infections. Whether this is the result of widespread adult vaccination or fundamental changes in the biology of SARS-CoV-2 remains to be determined. Here, we use primary nasal epithelial cells from children and adults, differentiated at an air-liquid interface to show that the ancestral SARS-CoV-2 replicates to significantly lower titers in the nasal epithelial cells of children compared to those of adults. This was associated with a heightened antiviral response to SARS-CoV-2 in the nasal epithelial cells of children. Importantly, the Delta variant also replicated to significantly lower titres in the nasal epithelial cells of children. This trend was markedly less pronounced in the case of Omicron. It is also striking to note that, at least in terms of viral RNA, Omicron replicated better in pediatric NECs compared to both Delta and the ancestral virus. Taken together, these data show that the nasal epithelium of children supports lower infection and replication of ancestral SARS-CoV-2, although this may be changing as the virus evolves." @default.
- W3134408072 created "2021-03-15" @default.
- W3134408072 creator A5004880091 @default.
- W3134408072 creator A5004987256 @default.
- W3134408072 creator A5013718219 @default.
- W3134408072 creator A5014525676 @default.
- W3134408072 creator A5017868804 @default.
- W3134408072 creator A5018267741 @default.
- W3134408072 creator A5019998413 @default.
- W3134408072 creator A5020343026 @default.
- W3134408072 creator A5025401318 @default.
- W3134408072 creator A5026852293 @default.
- W3134408072 creator A5029343344 @default.
- W3134408072 creator A5029653477 @default.
- W3134408072 creator A5033404457 @default.
- W3134408072 creator A5035023951 @default.
- W3134408072 creator A5040745079 @default.
- W3134408072 creator A5042448988 @default.
- W3134408072 creator A5048175603 @default.
- W3134408072 creator A5053063612 @default.
- W3134408072 creator A5054979401 @default.
- W3134408072 creator A5057668191 @default.
- W3134408072 creator A5061906689 @default.
- W3134408072 creator A5064461364 @default.
- W3134408072 creator A5068535817 @default.
- W3134408072 creator A5069789773 @default.
- W3134408072 creator A5083386931 @default.
- W3134408072 date "2021-03-08" @default.
- W3134408072 modified "2023-09-30" @default.
- W3134408072 title "Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells" @default.
- W3134408072 cites W2093588907 @default.
- W3134408072 cites W2107060225 @default.
- W3134408072 cites W2137526110 @default.
- W3134408072 cites W2146512944 @default.
- W3134408072 cites W2156208878 @default.
- W3134408072 cites W2164891013 @default.
- W3134408072 cites W2179438025 @default.
- W3134408072 cites W2413982537 @default.
- W3134408072 cites W2432815617 @default.
- W3134408072 cites W2592811885 @default.
- W3134408072 cites W3009912996 @default.
- W3134408072 cites W3010951319 @default.
- W3134408072 cites W3013947120 @default.
- W3134408072 cites W3017089760 @default.
- W3134408072 cites W3018829510 @default.
- W3134408072 cites W3022285953 @default.
- W3134408072 cites W3025141218 @default.
- W3134408072 cites W3026328714 @default.
- W3134408072 cites W3030748957 @default.
- W3134408072 cites W3035189381 @default.
- W3134408072 cites W3035338795 @default.
- W3134408072 cites W3037578804 @default.
- W3134408072 cites W3043831218 @default.
- W3134408072 cites W3081689218 @default.
- W3134408072 cites W3096139462 @default.
- W3134408072 cites W3096867322 @default.
- W3134408072 cites W3109705195 @default.
- W3134408072 cites W3111584233 @default.
- W3134408072 cites W3123124999 @default.
- W3134408072 cites W3125727696 @default.
- W3134408072 cites W3127108458 @default.
- W3134408072 cites W3142193354 @default.
- W3134408072 cites W3175817142 @default.
- W3134408072 cites W3179206042 @default.
- W3134408072 cites W3188239015 @default.
- W3134408072 cites W3188307511 @default.
- W3134408072 cites W3194090738 @default.
- W3134408072 cites W3198233589 @default.
- W3134408072 cites W3202714244 @default.
- W3134408072 cites W3211429308 @default.
- W3134408072 cites W4200391585 @default.
- W3134408072 cites W4200625712 @default.
- W3134408072 cites W4205514255 @default.
- W3134408072 cites W4206945609 @default.
- W3134408072 cites W4210421123 @default.
- W3134408072 cites W4210665241 @default.
- W3134408072 cites W4212938318 @default.
- W3134408072 cites W4213033002 @default.
- W3134408072 cites W4213182075 @default.
- W3134408072 cites W4213200965 @default.
- W3134408072 cites W4214610792 @default.
- W3134408072 cites W4226147054 @default.
- W3134408072 cites W4234228549 @default.
- W3134408072 doi "https://doi.org/10.1101/2021.03.08.434300" @default.
- W3134408072 hasPublicationYear "2021" @default.
- W3134408072 type Work @default.
- W3134408072 sameAs 3134408072 @default.
- W3134408072 citedByCount "7" @default.
- W3134408072 countsByYear W31344080722021 @default.
- W3134408072 countsByYear W31344080722022 @default.
- W3134408072 countsByYear W31344080722023 @default.
- W3134408072 crossrefType "posted-content" @default.
- W3134408072 hasAuthorship W3134408072A5004880091 @default.
- W3134408072 hasAuthorship W3134408072A5004987256 @default.
- W3134408072 hasAuthorship W3134408072A5013718219 @default.
- W3134408072 hasAuthorship W3134408072A5014525676 @default.
- W3134408072 hasAuthorship W3134408072A5017868804 @default.
- W3134408072 hasAuthorship W3134408072A5018267741 @default.
- W3134408072 hasAuthorship W3134408072A5019998413 @default.
- W3134408072 hasAuthorship W3134408072A5020343026 @default.