FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134421188> ?p ?o ?g. }

• W3134421188 abstract "Background: Sanguisorba Officinalis L. (SO) is a well-known traditional Chinese medicine (TCM), commonly applied to treat complex diseases, such as anticancer, antibacterial, antiviral, anti-inflammatory, anti-oxidant and hemostatic effects. Especially, it has been reported to exert anti-tumor effect in various human cancers. However, its effect and pharmacological mechanism on hepatocellular carcinoma (HCC) remains unclear. Methods: In this study, network pharmacology approach was applied to characterize the underlying mechanism of SO on HCC. Active compounds and potential targets of SO, as well as related genes of HCC were obtained from the public databases, the potential targets and signaling pathways were determined by protein-protein interaction (PPI), gene ontology (GO) and pathway enrichment analyses. And the compound-target and target-pathway networks were constructed. Subsequently, in vitro experiments were also performed to further verify the anticancer effects of SO on HCC. Results: By using the comprehensive network pharmacology analysis, 41 ingredients in SO were collected from the corresponding databases, 12 active ingredients screened according to their oral bioavailability and drug-likeness index, and 258 potential targets related to HCC were predicted. Through enrichment analysis, SO was found to show its excellent therapeutic effects on HCC through several pathways, mainly related to proliferation and survival via the EGFR, PI3K/AKT, NFκB and MAPK signaling pathways. Additionally, in vitro , SO was found to inhibit cell proliferation, induce apoptosis and down-regulate cell migration and invasion in various HCC cells. Moreover, western blot analysis showed that SO treatment down-regulated the expression of p-EGFR, p-PI3K, p-AKT, p-NFκB and p-MAPK proteins in HepG2 cells. These results validated that SO exerted its therapeutic effects on HCC mainly by the regulation of cell proliferation and survival via the EGFR/MAPK and EGFR/PI3K/AKT/NFκB signaling pathways. Conclusion: Taken together, this study, revealed the anti-HCC effects of SO and its potential underlying therapeutic mechanisms in a multi-target and multi-pathway manner." @default.
• W3134421188 created "2021-03-15" @default.
• W3134421188 creator A5014068004 @default.
• W3134421188 creator A5029815331 @default.
• W3134421188 creator A5050979366 @default.
• W3134421188 creator A5053881225 @default.
• W3134421188 creator A5056355591 @default.
• W3134421188 creator A5063495196 @default.
• W3134421188 creator A5086107148 @default.
• W3134421188 date "2021-03-04" @default.
• W3134421188 modified "2023-09-23" @default.
• W3134421188 title "Network Pharmacology and Pharmacological Evaluation Reveals the Mechanism of the Sanguisorba Officinalis in Suppressing Hepatocellular Carcinoma" @default.
• W3134421188 cites W1437374622 @default.
• W3134421188 cites W1787543413 @default.
• W3134421188 cites W1907401581 @default.
• W3134421188 cites W1973924418 @default.
• W3134421188 cites W1981452456 @default.
• W3134421188 cites W1987340528 @default.
• W3134421188 cites W1987612487 @default.
• W3134421188 cites W1988924112 @default.
• W3134421188 cites W1994193851 @default.
• W3134421188 cites W2001903432 @default.
• W3134421188 cites W2009886463 @default.
• W3134421188 cites W2038625523 @default.
• W3134421188 cites W2047998870 @default.
• W3134421188 cites W2055903690 @default.
• W3134421188 cites W2063280109 @default.
• W3134421188 cites W2075525547 @default.
• W3134421188 cites W2076804940 @default.
• W3134421188 cites W2096108416 @default.
• W3134421188 cites W2108391445 @default.
• W3134421188 cites W2124679671 @default.
• W3134421188 cites W2133559579 @default.
• W3134421188 cites W2144563376 @default.
• W3134421188 cites W2158217645 @default.
• W3134421188 cites W2159675211 @default.
• W3134421188 cites W2159898382 @default.
• W3134421188 cites W2168938595 @default.
• W3134421188 cites W2210526074 @default.
• W3134421188 cites W2215047099 @default.
• W3134421188 cites W2277004004 @default.
• W3134421188 cites W2279201083 @default.
• W3134421188 cites W2292118970 @default.
• W3134421188 cites W2315613727 @default.
• W3134421188 cites W2474747771 @default.
• W3134421188 cites W2554940281 @default.
• W3134421188 cites W2559588208 @default.
• W3134421188 cites W2592759098 @default.
• W3134421188 cites W2598230851 @default.
• W3134421188 cites W2720897370 @default.
• W3134421188 cites W2743664249 @default.
• W3134421188 cites W2744377419 @default.
• W3134421188 cites W2744768154 @default.
• W3134421188 cites W2754281214 @default.
• W3134421188 cites W2754437817 @default.
• W3134421188 cites W2760763508 @default.
• W3134421188 cites W2787229753 @default.
• W3134421188 cites W2889646458 @default.
• W3134421188 cites W2900569176 @default.
• W3134421188 cites W2901488993 @default.
• W3134421188 cites W2924328881 @default.
• W3134421188 cites W2928431398 @default.
• W3134421188 cites W2947325496 @default.
• W3134421188 cites W2954043109 @default.
• W3134421188 cites W2955896228 @default.
• W3134421188 cites W2958029267 @default.
• W3134421188 cites W3000070916 @default.
• W3134421188 cites W3001416610 @default.
• W3134421188 cites W3005722875 @default.
• W3134421188 cites W3006997784 @default.
• W3134421188 cites W3008957256 @default.
• W3134421188 cites W4210955410 @default.
• W3134421188 cites W4233120011 @default.
• W3134421188 cites W4254138536 @default.
• W3134421188 cites W978308701 @default.
• W3134421188 doi "https://doi.org/10.3389/fphar.2021.618522" @default.
• W3134421188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7969657" @default.
• W3134421188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33746755" @default.
• W3134421188 hasPublicationYear "2021" @default.
• W3134421188 type Work @default.
• W3134421188 sameAs 3134421188 @default.
• W3134421188 citedByCount "17" @default.
• W3134421188 countsByYear W31344211882021 @default.
• W3134421188 countsByYear W31344211882022 @default.
• W3134421188 countsByYear W31344211882023 @default.
• W3134421188 crossrefType "journal-article" @default.
• W3134421188 hasAuthorship W3134421188A5014068004 @default.
• W3134421188 hasAuthorship W3134421188A5029815331 @default.
• W3134421188 hasAuthorship W3134421188A5050979366 @default.
• W3134421188 hasAuthorship W3134421188A5053881225 @default.
• W3134421188 hasAuthorship W3134421188A5056355591 @default.
• W3134421188 hasAuthorship W3134421188A5063495196 @default.
• W3134421188 hasAuthorship W3134421188A5086107148 @default.
• W3134421188 hasBestOaLocation W31344211881 @default.
• W3134421188 hasConcept C111472728 @default.
• W3134421188 hasConcept C138885662 @default.
• W3134421188 hasConcept C190283241 @default.
• W3134421188 hasConcept C2778019345 @default.
• W3134421188 hasConcept C502942594 @default.
• W3134421188 hasConcept C55493867 @default.

• next