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- W3134423894 abstract "Aims & Objectives: To assess the rate, risk factors and outcome of AKI in children with hematological malignancy admitted in pediatric Intensive care unit (PICU). Methods: Retrospective, cross-sectional study on critically ill children with hematological malignancies and developed AKI and admitted in PICU from July 2017 to June 2019. Demographic data, clinical profile, and outcome were included. AKI was defined according to Kidney Disease: Improving Global Outcomes (KIDGO) criteria Results: Of 399 critically ill children with hematological malignancy, 85 (31.33%) patients developed AKI. The mean age was 7.8±3.8 years and 66% were male of entire cohort. The most common diagnosis was Acute Lymphoblastic Leukemia (50%). Dialyitc therapy was initiated in 9 patients (2.3%) only. The risk factors for AKI were Tumor Lysis syndrome (p-value 0.001), exposure to nephrotoxic drugs (p <0.001), septic shock (p <0.001), use of mechanical ventilation (p <0.001), need of vasoactive drugs (p <0.001) and age (p <0.001). Kaplan-Meier survival analysis showed median survival time in children with AKI was 11 days (95%CI- 7.6 – 14.4) while median survival time in children without AKI is significantly high (Log rank test- p-value <0.001). By multivariate analysis, AKI is independent risk factor for mortality [OR20.02; 95%CI 8.14-49.28; p <0.001].The mortality rate was 63.5% in patients with AKI and 8.6% in patients without AKI (p <0.001). Conclusions: AKI occurred in 21.3% in critically ill children with hematological malignancies and is associated with age, organ dysfunction, sepsis, tumor lysis syndrome and exposure of nephrotoxic drugs. AKI is an independent risk factor for high mortality rate." @default.
- W3134423894 created "2021-03-15" @default.
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- W3134423894 date "2021-03-01" @default.
- W3134423894 modified "2023-09-26" @default.
- W3134423894 title "P0146 / #1864: RATE, RISK FACTORS AND OUTCOME OF ACUTE KIDNEY INJURY IN CRITICALLY ILL CHILDREN WITH HEMATOLOGICAL MALIGNANCIES" @default.
- W3134423894 doi "https://doi.org/10.1097/01.pcc.0000738928.20957.a7" @default.
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