Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134491872> ?p ?o ?g. }
- W3134491872 abstract "Abstract Background Obesity and its associated conditions, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), are a particular worldwide health problem at present. Momordica cochinchinensis fruit is consumed widely in Southeast Asia. However, whether it has functional effects on fat-induced metabolic dysfunction and gut microbiota remains unclear. This study was conducted to determine how Momordica cochinchinensis aril (MCA) affects obesity, nonalcoholic fatty liver, insulin resistance and gut microbiota in diet-induced obese mice.Methods Wild type male mice at age of 5 weeks received four different kinds of diets: a normal diet, high-fat diet (HFD), or HFD supplemented with 1% or 3% (wt:wt) lyophilized MCA for 10 weeks. Body weight, adipose tissue and liver weight, serum biochemical parameters, glucose tolerance and liver lipids were measured. Gut microbial composition was analyzed.Results MCA protected the mice against high-fat diet (HFD)-induced body weight gain, hyperlipidemia and hyperglycemia, compared with mice that were not treated. MCA inhibited the expansion of adipose tissue and adipocyte hypertrophy. In addition, the insulin sensitivity-associated index that evaluates insulin function was also significantly restored. MCA also regulated the secretion of adipokines in HFD-induced obese mice. Moreover, hepatic fat accumulation and liver inflammation were reduced, which suggested that fatty liver was prevented by MCA. Furthermore, MCA supplementation suppressed hepatic lipid accumulation by activation of AMPK and PPAR-alpha signaling pathway in the human fatty liver HuS-E/2 cell model. Supplementation with MCA resulted in microbiota populations changed significantly.Conclusion Our data indicate that dietary MCA is involved in the prevention of HFD-induced adiposity, insulin resistance and nonalcoholic fatty liver disease and altered the microbial contents of the gut and modulated microbial dysbiosis in the host." @default.
- W3134491872 created "2021-03-15" @default.
- W3134491872 creator A5000130181 @default.
- W3134491872 creator A5030949828 @default.
- W3134491872 creator A5035069512 @default.
- W3134491872 creator A5036253440 @default.
- W3134491872 creator A5047695560 @default.
- W3134491872 creator A5052036747 @default.
- W3134491872 creator A5080760900 @default.
- W3134491872 creator A5081629472 @default.
- W3134491872 date "2020-01-07" @default.
- W3134491872 modified "2023-09-26" @default.
- W3134491872 title "Dietary Momordica Cochinchinensis aril ameliorates metabolic dysfunction, nonalcoholic fatty liver, and gut microbiota in diet-induced obese mice" @default.
- W3134491872 cites W1506095972 @default.
- W3134491872 cites W1861209549 @default.
- W3134491872 cites W1927710737 @default.
- W3134491872 cites W1965542075 @default.
- W3134491872 cites W1977142891 @default.
- W3134491872 cites W1980051966 @default.
- W3134491872 cites W1981888773 @default.
- W3134491872 cites W1986310963 @default.
- W3134491872 cites W2005294551 @default.
- W3134491872 cites W2009377963 @default.
- W3134491872 cites W2025064703 @default.
- W3134491872 cites W2028212562 @default.
- W3134491872 cites W2047726312 @default.
- W3134491872 cites W2053342834 @default.
- W3134491872 cites W2067791097 @default.
- W3134491872 cites W2071045558 @default.
- W3134491872 cites W2075881404 @default.
- W3134491872 cites W2076576023 @default.
- W3134491872 cites W2077072558 @default.
- W3134491872 cites W2080130381 @default.
- W3134491872 cites W2114825009 @default.
- W3134491872 cites W2115692333 @default.
- W3134491872 cites W2118508294 @default.
- W3134491872 cites W2119160774 @default.
- W3134491872 cites W2123839175 @default.
- W3134491872 cites W2124664603 @default.
- W3134491872 cites W2137884117 @default.
- W3134491872 cites W2141314779 @default.
- W3134491872 cites W2148824946 @default.
- W3134491872 cites W2158569927 @default.
- W3134491872 cites W2159686118 @default.
- W3134491872 cites W2160013852 @default.
- W3134491872 cites W2167062509 @default.
- W3134491872 cites W2280085712 @default.
- W3134491872 cites W2344792412 @default.
- W3134491872 cites W2401404581 @default.
- W3134491872 cites W2474139832 @default.
- W3134491872 cites W2521134781 @default.
- W3134491872 cites W2581473381 @default.
- W3134491872 cites W2610755648 @default.
- W3134491872 cites W2746430677 @default.
- W3134491872 cites W2772633870 @default.
- W3134491872 cites W2807194798 @default.
- W3134491872 cites W2898041020 @default.
- W3134491872 cites W4245344195 @default.
- W3134491872 doi "https://doi.org/10.21203/rs.2.20237/v1" @default.
- W3134491872 hasPublicationYear "2020" @default.
- W3134491872 type Work @default.
- W3134491872 sameAs 3134491872 @default.
- W3134491872 citedByCount "0" @default.
- W3134491872 crossrefType "posted-content" @default.
- W3134491872 hasAuthorship W3134491872A5000130181 @default.
- W3134491872 hasAuthorship W3134491872A5030949828 @default.
- W3134491872 hasAuthorship W3134491872A5035069512 @default.
- W3134491872 hasAuthorship W3134491872A5036253440 @default.
- W3134491872 hasAuthorship W3134491872A5047695560 @default.
- W3134491872 hasAuthorship W3134491872A5052036747 @default.
- W3134491872 hasAuthorship W3134491872A5080760900 @default.
- W3134491872 hasAuthorship W3134491872A5081629472 @default.
- W3134491872 hasConcept C126322002 @default.
- W3134491872 hasConcept C134018914 @default.
- W3134491872 hasConcept C171089720 @default.
- W3134491872 hasConcept C203014093 @default.
- W3134491872 hasConcept C2776175234 @default.
- W3134491872 hasConcept C2776175330 @default.
- W3134491872 hasConcept C2776954865 @default.
- W3134491872 hasConcept C2777180221 @default.
- W3134491872 hasConcept C2777391703 @default.
- W3134491872 hasConcept C2778772119 @default.
- W3134491872 hasConcept C2779134260 @default.
- W3134491872 hasConcept C539455810 @default.
- W3134491872 hasConcept C555293320 @default.
- W3134491872 hasConcept C71924100 @default.
- W3134491872 hasConcept C86803240 @default.
- W3134491872 hasConceptScore W3134491872C126322002 @default.
- W3134491872 hasConceptScore W3134491872C134018914 @default.
- W3134491872 hasConceptScore W3134491872C171089720 @default.
- W3134491872 hasConceptScore W3134491872C203014093 @default.
- W3134491872 hasConceptScore W3134491872C2776175234 @default.
- W3134491872 hasConceptScore W3134491872C2776175330 @default.
- W3134491872 hasConceptScore W3134491872C2776954865 @default.
- W3134491872 hasConceptScore W3134491872C2777180221 @default.
- W3134491872 hasConceptScore W3134491872C2777391703 @default.
- W3134491872 hasConceptScore W3134491872C2778772119 @default.
- W3134491872 hasConceptScore W3134491872C2779134260 @default.
- W3134491872 hasConceptScore W3134491872C539455810 @default.
- W3134491872 hasConceptScore W3134491872C555293320 @default.