Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134493801> ?p ?o ?g. }
- W3134493801 abstract "Significance Sepsis is a condition wherein a microbial infection leads to life-threatening systemic hyperactivation of innate immunity. Blood pH is normally maintained tightly between 7.35 and 7.45, and lactic acidosis with a pH <7.3 indicates a poor prognosis in sepsis, also associated with low zinc levels. Release of HMGB1 from activated and/or necrotic tissues plays a pivotal role in triggering the proinflammatory cascade of late sepsis. Using an in vitro whole-blood assay, we observed that HMGB1 cannot mediate proinflammatory activity at physiological pH and zinc concentrations. This is due to zinc-dependent association of HMGB1 with sialoglycoproteins, thereby preventing its binding with proinflammatory receptors. Thus, a drop in pH and zinc concentration in sepsis can release sequestered HMGB1 and trigger the inflammatory cascade." @default.
- W3134493801 created "2021-03-15" @default.
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- W3134493801 date "2021-03-03" @default.
- W3134493801 modified "2023-10-02" @default.
- W3134493801 title "Sialoglycan recognition is a common connection linking acidosis, zinc, and HMGB1 in sepsis" @default.
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- W3134493801 doi "https://doi.org/10.1073/pnas.2018090118" @default.
- W3134493801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7958265" @default.