FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134499465> ?p ?o ?g. }

• W3134499465 abstract "Abstract Understanding the functional consequences of genetic variation in the non-coding regions of the human genome remains a challenge. We introduce here a computational tool, TURF, to prioritize regulatory variants with tissue-specific function by leveraging evidence from functional genomics experiments, including over three thousand functional genomics datasets from the ENCODE project provided in the RegulomeDB database. TURF is able to generate prediction scores at both organism and tissue/organ-specific levels for any non-coding variant on the genome. We present that TURF has an overall top performance in prediction by using validated variants from MPRA experiments. We also demonstrate how TURF can pick out the regulatory variants with tissue-specific function over a candidate list from associate studies. Furthermore, we found that various GWAS traits showed the enrichment of regulatory variants predicted by TURF scores in the trait-relevant organs, which indicates that these variants can be a valuable source for future studies." @default.
• W3134499465 created "2021-03-15" @default.
• W3134499465 creator A5018760379 @default.
• W3134499465 creator A5039809808 @default.
• W3134499465 date "2021-03-09" @default.
• W3134499465 modified "2023-10-14" @default.
• W3134499465 title "Prioritization of regulatory variants with tissue-specific function in the non-coding regions of human genome" @default.
• W3134499465 cites W1019830208 @default.
• W3134499465 cites W1639665852 @default.
• W3134499465 cites W1989004527 @default.
• W3134499465 cites W1995840194 @default.
• W3134499465 cites W2015416439 @default.
• W3134499465 cites W2017840637 @default.
• W3134499465 cites W2023342647 @default.
• W3134499465 cites W2033202128 @default.
• W3134499465 cites W2076154138 @default.
• W3134499465 cites W2078059415 @default.
• W3134499465 cites W2079177924 @default.
• W3134499465 cites W2080291586 @default.
• W3134499465 cites W2084160423 @default.
• W3134499465 cites W2092390808 @default.
• W3134499465 cites W2104549677 @default.
• W3134499465 cites W2122732537 @default.
• W3134499465 cites W2129795133 @default.
• W3134499465 cites W2134199796 @default.
• W3134499465 cites W2141820415 @default.
• W3134499465 cites W2149118429 @default.
• W3134499465 cites W2150506261 @default.
• W3134499465 cites W2152435464 @default.
• W3134499465 cites W2159664283 @default.
• W3134499465 cites W2160995259 @default.
• W3134499465 cites W2168133698 @default.
• W3134499465 cites W2195359644 @default.
• W3134499465 cites W2198606573 @default.
• W3134499465 cites W2259938310 @default.
• W3134499465 cites W2336509392 @default.
• W3134499465 cites W2338876157 @default.
• W3134499465 cites W2597215890 @default.
• W3134499465 cites W2618913536 @default.
• W3134499465 cites W2767826728 @default.
• W3134499465 cites W2799622612 @default.
• W3134499465 cites W2887303615 @default.
• W3134499465 cites W2901303766 @default.
• W3134499465 cites W2901757429 @default.
• W3134499465 cites W2903347564 @default.
• W3134499465 cites W2944540884 @default.
• W3134499465 cites W2945239551 @default.
• W3134499465 cites W2949073843 @default.
• W3134499465 cites W2951962793 @default.
• W3134499465 cites W2952239877 @default.
• W3134499465 cites W2972605721 @default.
• W3134499465 doi "https://doi.org/10.1101/2021.03.09.434619" @default.
• W3134499465 hasPublicationYear "2021" @default.
• W3134499465 type Work @default.
• W3134499465 sameAs 3134499465 @default.
• W3134499465 citedByCount "1" @default.
• W3134499465 countsByYear W31344994652022 @default.
• W3134499465 crossrefType "posted-content" @default.
• W3134499465 hasAuthorship W3134499465A5018760379 @default.
• W3134499465 hasAuthorship W3134499465A5039809808 @default.
• W3134499465 hasBestOaLocation W31344994651 @default.
• W3134499465 hasConcept C104317684 @default.
• W3134499465 hasConcept C106208931 @default.
• W3134499465 hasConcept C135763542 @default.
• W3134499465 hasConcept C14036430 @default.
• W3134499465 hasConcept C141231307 @default.
• W3134499465 hasConcept C153209595 @default.
• W3134499465 hasConcept C161078062 @default.
• W3134499465 hasConcept C162324750 @default.
• W3134499465 hasConcept C168393362 @default.
• W3134499465 hasConcept C189206191 @default.
• W3134499465 hasConcept C197077220 @default.
• W3134499465 hasConcept C2777615720 @default.
• W3134499465 hasConcept C539667460 @default.
• W3134499465 hasConcept C54355233 @default.
• W3134499465 hasConcept C66746571 @default.
• W3134499465 hasConcept C70721500 @default.
• W3134499465 hasConcept C86803240 @default.
• W3134499465 hasConceptScore W3134499465C104317684 @default.
• W3134499465 hasConceptScore W3134499465C106208931 @default.
• W3134499465 hasConceptScore W3134499465C135763542 @default.
• W3134499465 hasConceptScore W3134499465C14036430 @default.
• W3134499465 hasConceptScore W3134499465C141231307 @default.
• W3134499465 hasConceptScore W3134499465C153209595 @default.
• W3134499465 hasConceptScore W3134499465C161078062 @default.
• W3134499465 hasConceptScore W3134499465C162324750 @default.
• W3134499465 hasConceptScore W3134499465C168393362 @default.
• W3134499465 hasConceptScore W3134499465C189206191 @default.
• W3134499465 hasConceptScore W3134499465C197077220 @default.
• W3134499465 hasConceptScore W3134499465C2777615720 @default.
• W3134499465 hasConceptScore W3134499465C539667460 @default.
• W3134499465 hasConceptScore W3134499465C54355233 @default.
• W3134499465 hasConceptScore W3134499465C66746571 @default.
• W3134499465 hasConceptScore W3134499465C70721500 @default.
• W3134499465 hasConceptScore W3134499465C86803240 @default.
• W3134499465 hasLocation W31344994651 @default.
• W3134499465 hasOpenAccess W3134499465 @default.
• W3134499465 hasPrimaryLocation W31344994651 @default.
• W3134499465 hasRelatedWork W2004424045 @default.
• W3134499465 hasRelatedWork W2089001634 @default.

• next