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- W3134523629 abstract "A presynaptic protein closely related to Parkinson's disease (PD), α-synuclein (α-Syn), has been studied extensively regarding its pathogenic mechanisms. As a physiological protein in presynapses, however, α-Syn's physiological function remains unclear. Its location in nerve terminals and effects on membrane fusion also imply its functional role in synaptic transmission, including its possible interaction with high-curvature membranes via its N-terminus and amorphous C-terminus. PD-related mutants that disrupt the membrane interaction (e.g., A30P and G51D) additionally suggest a relationship between α-Syn's pathogenic mechanisms and physiological roles through the membrane binding. Here, we summarize recent research on how α-Syn and its variants interact with membranes and influence synaptic transmission. We list several membrane-related connections between the protein's physiological function and the pathological mechanisms that stand to expand current understandings of α-Syn." @default.
- W3134523629 created "2021-03-15" @default.
- W3134523629 creator A5015109878 @default.
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- W3134523629 creator A5043522608 @default.
- W3134523629 creator A5047212198 @default.
- W3134523629 creator A5062451757 @default.
- W3134523629 date "2021-03-04" @default.
- W3134523629 modified "2023-10-18" @default.
- W3134523629 title "The Membrane Interaction of Alpha-Synuclein" @default.
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- W3134523629 doi "https://doi.org/10.3389/fncel.2021.633727" @default.
- W3134523629 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7969880" @default.
- W3134523629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33746714" @default.
- W3134523629 hasPublicationYear "2021" @default.
- W3134523629 type Work @default.
- W3134523629 sameAs 3134523629 @default.