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- W3134543565 abstract "Amyloidosis consists of approximately 30 protein-folding disorders in which a specific soluble precursor protein aggregates to form the insoluble fibrils of amyloid. Insulin is the hypothesized precursor protein in localized cutaneous insulin-derived (AIns) amyloidosis. Amyloid deposition at insulin injection sites can interfere with absorption, leading to poor glucose control. Despite the increasing prevalence of diabetes mellitus and insulin use, there is a paucity of published cases of AIns amyloidosis and a lack of awareness of this condition among both dermatologists and general practitioners. We report 2 patients with insulin-dependent diabetes who developed hyperkeratotic nodules at insulin injection sites. Our cases complement the current data on iatrogenic amyloidosis and provide insight into this likely underreported phenomenon." @default.
- W3134543565 created "2021-03-15" @default.
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- W3134543565 date "2021-01-01" @default.
- W3134543565 modified "2023-09-26" @default.
- W3134543565 title "Cutaneous Insulin-Derived Amyloidosis Presenting as Hyperkeratotic Nodules" @default.
- W3134543565 cites W1981638035 @default.
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- W3134543565 doi "https://doi.org/10.12788/cutis.0161" @default.
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