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• W3134547301 startingPage "101937" @default.
• W3134547301 abstract "Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western nations and characterized by excessive accumulation of lipids in the liver. In this narrative review, we summarize the evidence from human trials that free radical-induced oxidation of macromolecules, in particular of lipids, is a characteristic feature of NAFLD and non-alcoholic steatohepatitis (NASH). We further synthesize the data in the scientific literature describing the impact of vitamin E (mainly α-tocopherol) on concentrations of redox biomarkers in liver biopsies from patients with NAFLD as well as animal experiments. In summary, the available evidence from clinical trials suggests that reactive species-mediated damage to macromolecules, predominantly lipids, occurs in NAFLD and NASH and that daily supplementation with at least 200 I.U. α-tocopherol may alleviate oxidative stress in the liver of NAFLD patients. We propose α-tocopherol as a useful model substance to identify and validate suitable redox biomarkers that may be employed in future clinical trials of new therapeutics for NAFLD." @default.
• W3134547301 created "2021-03-15" @default.
• W3134547301 creator A5026065388 @default.
• W3134547301 creator A5071961324 @default.
• W3134547301 date "2021-06-01" @default.
• W3134547301 modified "2023-10-16" @default.
• W3134547301 title "Impact of vitamin E on redox biomarkers in non-alcoholic fatty liver disease" @default.
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• W3134547301 doi "https://doi.org/10.1016/j.redox.2021.101937" @default.
• W3134547301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8113042" @default.
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• W3134547301 hasPublicationYear "2021" @default.
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