Matches in SemOpenAlex for { <https://semopenalex.org/work/W3134549131> ?p ?o ?g. }
- W3134549131 abstract "Summary Despite redundant cellular pathways to minimize translational errors, errors in protein synthesis are common. Pathways and mechanisms to minimize errors are classified as pre-ribosomal or ribosomal. Pre-ribosomal pathways are primarily concerned with appropriate pairing of tRNAs with their cognate amino acid, whereas to date, ribosomal proof-reading has been thought to only be concerned with minimizing decoding errors, since it has been assumed that the ribosomal decoding centre is blind to mischarged tRNAs. Here, we identified that in mycobacteria, deletion of the 16S ribosomal RNA methyltransferase gidB led to increased discrimination of mischarged tRNAs. GidB deletion was necessary but not sufficient for reducing mistranslation due to misacylation. Discrimination only occurred in mycobacteria enriched from environments or genetic backgrounds with high rates of mistranslation. Our data suggest that mycobacterial ribosomes are capable of discriminating mischarged tRNAs and that 16S rRNA methylation by GidB may act as a capacitor for moderating translational error." @default.
- W3134549131 created "2021-03-15" @default.
- W3134549131 creator A5016374593 @default.
- W3134549131 creator A5018858170 @default.
- W3134549131 creator A5024237203 @default.
- W3134549131 creator A5027102881 @default.
- W3134549131 date "2021-03-03" @default.
- W3134549131 modified "2023-09-27" @default.
- W3134549131 title "Ribosomal RNA methylation by GidB is a capacitor for discrimination of mischarged tRNA" @default.
- W3134549131 cites W1540505601 @default.
- W3134549131 cites W1803919777 @default.
- W3134549131 cites W1819477483 @default.
- W3134549131 cites W1966840835 @default.
- W3134549131 cites W1967457339 @default.
- W3134549131 cites W1976678081 @default.
- W3134549131 cites W1977317496 @default.
- W3134549131 cites W1993111592 @default.
- W3134549131 cites W1993446851 @default.
- W3134549131 cites W2002895409 @default.
- W3134549131 cites W2010731297 @default.
- W3134549131 cites W2011753511 @default.
- W3134549131 cites W2016085798 @default.
- W3134549131 cites W2018793220 @default.
- W3134549131 cites W2021173027 @default.
- W3134549131 cites W2027295832 @default.
- W3134549131 cites W2032592004 @default.
- W3134549131 cites W2034108516 @default.
- W3134549131 cites W2035145746 @default.
- W3134549131 cites W2039645753 @default.
- W3134549131 cites W2041034033 @default.
- W3134549131 cites W2042227411 @default.
- W3134549131 cites W2044917835 @default.
- W3134549131 cites W2050971165 @default.
- W3134549131 cites W2052099724 @default.
- W3134549131 cites W2055347597 @default.
- W3134549131 cites W2057781025 @default.
- W3134549131 cites W2064580738 @default.
- W3134549131 cites W2066392481 @default.
- W3134549131 cites W2076946494 @default.
- W3134549131 cites W2080453586 @default.
- W3134549131 cites W2088630421 @default.
- W3134549131 cites W2095346908 @default.
- W3134549131 cites W2118391959 @default.
- W3134549131 cites W2118667931 @default.
- W3134549131 cites W2127352765 @default.
- W3134549131 cites W2132152341 @default.
- W3134549131 cites W2132439282 @default.
- W3134549131 cites W2140425855 @default.
- W3134549131 cites W2141997506 @default.
- W3134549131 cites W2147302373 @default.
- W3134549131 cites W2158624607 @default.
- W3134549131 cites W2163209588 @default.
- W3134549131 cites W2163667700 @default.
- W3134549131 cites W2211723875 @default.
- W3134549131 cites W2288549395 @default.
- W3134549131 cites W2298792983 @default.
- W3134549131 cites W2341166238 @default.
- W3134549131 cites W2466599087 @default.
- W3134549131 cites W2508609323 @default.
- W3134549131 cites W2525493632 @default.
- W3134549131 cites W2557904026 @default.
- W3134549131 cites W2576247252 @default.
- W3134549131 cites W2605302163 @default.
- W3134549131 cites W2605410679 @default.
- W3134549131 cites W2742361316 @default.
- W3134549131 cites W2745768305 @default.
- W3134549131 cites W2765763408 @default.
- W3134549131 cites W2770921477 @default.
- W3134549131 cites W2789689928 @default.
- W3134549131 cites W2809794503 @default.
- W3134549131 cites W2810772875 @default.
- W3134549131 cites W2884058580 @default.
- W3134549131 cites W2885437209 @default.
- W3134549131 cites W2889530149 @default.
- W3134549131 cites W2894927071 @default.
- W3134549131 cites W2895461480 @default.
- W3134549131 cites W2926617210 @default.
- W3134549131 cites W2940518284 @default.
- W3134549131 cites W2944083878 @default.
- W3134549131 cites W2971364670 @default.
- W3134549131 cites W2979711645 @default.
- W3134549131 cites W3005144567 @default.
- W3134549131 cites W3016984298 @default.
- W3134549131 cites W3033907609 @default.
- W3134549131 cites W3046146216 @default.
- W3134549131 cites W3088306137 @default.
- W3134549131 cites W3110376174 @default.
- W3134549131 cites W3027106315 @default.
- W3134549131 doi "https://doi.org/10.1101/2021.03.02.433644" @default.
- W3134549131 hasPublicationYear "2021" @default.
- W3134549131 type Work @default.
- W3134549131 sameAs 3134549131 @default.
- W3134549131 citedByCount "0" @default.
- W3134549131 crossrefType "posted-content" @default.
- W3134549131 hasAuthorship W3134549131A5016374593 @default.
- W3134549131 hasAuthorship W3134549131A5018858170 @default.
- W3134549131 hasAuthorship W3134549131A5024237203 @default.
- W3134549131 hasAuthorship W3134549131A5027102881 @default.
- W3134549131 hasBestOaLocation W31345491311 @default.
- W3134549131 hasConcept C104317684 @default.